[Sleep-disordered breathing and cardiac arrhythmias].
[Sleep-disordered breathing and cardiac arrhythmias].
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DOI：
10.1007/s00399-011-0164-8
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发表时间：
2012-03-01
期刊：
影响因子：
--
通讯作者：
Oldenburg, O
中科院分区：
文献类型：
--
作者：
Bitter, T;Korber, B;Oldenburg, O
睡眠呼吸障碍（SDB）是心律失常患者的重要合并症。既往研究证实室上性和室性心律失常与SDB之间存在相关性。在心力衰竭患者中，还发现SDB与发生需要适当心律转复除颤器治疗的恶性室性心律失常的无事件生存期较短独立相关。在阻塞性睡眠呼吸暂停中，反复低氧血症、机械应力（室壁张力）、睡眠唤醒和交感神经系统激活促进心律失常。Cheyne-Stokes呼吸和恶性心律失常之间联系的病理生理学概念尚未完全理解，需要进一步研究。此外，大规模的随机对照试验正在等待，以证明SDB的充分治疗是否与心律失常的发生风险降低有关，一般而言，特别是在这些患者中的恶性室性心律失常。
Sleep-disordered breathing (SDB) is an important comorbidity in patients with cardiac arrhythmias. Previous studies confirmed associations between supraventricular and ventricular arrhythmias and SDB. In heart failure patients, SDB was also found independently associated with a shorter event-free survival to the occurrence of malignant ventricular arrhythmias requiring appropriate cardioverter-defibrillator therapy. In obstructive sleep apnea, repetitive hypoxemia, mechanical stress (wall tension), arousals from sleep, and activation of the sympathetic nervous system promote cardiac arrhythmias. Pathophysiological concepts for the link between Cheyne-Stokes respiration and malignant arrhythmias are not fully understood and require further research. In addition, large-scale, randomized, controlled trials are awaited to prove whether adequate treatment of SDB is associated with a risk reduction for the occurrence of arrhythmias, in general, and malignant ventricular arrhythmias, in particular, in these patients.