T2 mapping in the knee after microfracture at 3.0 T:: correlation of global T2 values and clinical outcome -: preliminary results
T2 mapping in the knee after microfracture at 3.0 T:: correlation of global T2 values and clinical outcome -: preliminary results
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DOI：
10.1016/j.joca.2007.11.014
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发表时间：
2008-08-01
影响因子：
7
通讯作者：
Trattnig, S.
中科院分区：
文献类型：
--
作者：
Domayer, S. E.;Kutscha-Lissberg, F.;Trattnig, S.
目的：我们研究的目的是将微骨折修复组织 (RT) 的整体 T2 值与膝关节的临床结果相关联。方法：我们评估了 24 名接受膝关节微骨折治疗的患者。磁共振 (MR) 检查在 3 T MR 装置上进行，T2 弛豫时间通过多回波自旋回波技术获得。 T2 图是使用像素级、单指数非负最小二乘拟合分析获得的。选择覆盖软骨 FIT 的切片并进行感兴趣区域分析。使用 FIT 的全局平均 T2 和正常透明软骨的全局平均 T2 计算个体 T2 指数。 Lysholm 评分和国际膝关节文献委员会 (IKDC) 膝关节评估表用于评估临床结果。采用双变量相关分析和配对双尾 t 检验进行统计。结果：RT 的全局 T2 值[平均 49.8 ms，标准差 (SD) 7.5] 与正常透明软骨的全局 T2 值（平均 58.5 ms，SID 7.0）显着不同（P < 0.001）。 T2指数范围为61.3至101.5。我们发现 T2 指数与 Lysholm 评分结果相关（r(s) = 0.641，P < 0.001）和 IKDC 主观膝关节评估表（r, = 0.549，P= 0.005），而与 IKDC 膝关节评分结果没有相关性（r(s) = -0.284，P = 0.179）。结论：这些发现表明 T2 映射对于评估 RT 功能非常敏感，并为微骨折监测中的形态学 MRI 提供附加信息。 (c) 2007 年国际骨关节炎研究协会。由爱思唯尔有限公司出版。保留所有权利。
Objective: The aim of our study was to correlate global T2 values of microfracture repair tissue (RT) with clinical outcome in the knee joint.Methods: We assessed 24 patients treated with microfracture in the knee joint. Magnetic resonance (MR) examinations were performed on a 3 T MR unit, T2 relaxation times were obtained with a multi-echo spin-echo technique. T2 maps were obtained using a pixel wise, monoexponential non-negative least squares fit analysis. Slices covering the cartilage FIT were selected and region of interest analysis was done. An individual T2 index was calculated with global mean T2 of the FIT and global mean T2 of normal, hyaline cartilage. The Lysholm score and the International Knee Documentation Committee (IKDC) knee evaluation forms were used for the assessment of clinical outcome. Bivariate correlation analysis and a paired, two tailed t test were used for statistics.Results: Global T2 values of the RT [mean 49.8 ms, standards deviation (SD) 7.5] differed significantly (P < 0.001) from global T2 values of normal, hyaline cartilage (mean 58.5 ms, SID 7.0). The T2 index ranged from 61.3 to 101.5. We found the T2 index to correlate with outcome of the Lysholm score (r(s) = 0.641, P < 0.001) and the IKDC subjective knee evaluation form (r, = 0.549, P= 0.005), whereas there was no correlation with the IKDC knee form (r(s) = -0.284, P= 0.179).Conclusion: These findings indicate that T2 mapping is sensitive to assess RT function and provides additional information to morphologic MRI in the monitoring of microfracture. (c) 2007 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.