Group B Streptococcus (GBS) Colonization and Disease among Pregnant Women: A Historical Cohort Study.
Group B Streptococcus (GBS) Colonization and Disease among Pregnant Women: A Historical Cohort Study.
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DOI：
10.1155/2019/5430493
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发表时间：
2019-01-01
影响因子：
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通讯作者：
Swamy, Geeta K
中科院分区：
文献类型：
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作者：
Edwards, James M;Watson, Nora;Swamy, Geeta K
背景：母体 GBS 定植与早发性新生儿败血症有关，人们正在努力预防这种并发症。人们对 GBS 定植的母体风险知之甚少。我们寻求对孕产妇 GBS 定植和侵袭性 GBS 疾病的发病率和影响进行现代估计。方法：对 2003 年至 2015 年间所有出生的婴儿进行单中心历史队列研究。使用机构特定工具通过电子健康记录抽象来收集数据。对 GBS 状态进行描述性统计。对有和没有 GBS 定植的队列以及有 GBS 定植和侵袭性 GBS 疾病的队列进行推论统计，比较不良妊娠结局的风险。 结果：总共纳入 60,029 例分娩进行分析。总体而言，21.6% 的人口患有 GBS 定植，0.1% 患有侵袭性 GBS 疾病。 GBS 定植与母亲年龄较小、黑人种族、非西班牙裔种族、慢性高血压、既往糖尿病和吸烟有关（p
Background: Maternal GBS colonization is associated with early-onset neonatal sepsis and extensive efforts are directed to preventing this complication. Less is known about maternal risks of GBS colonization. We seek to provide a modern estimate of the incidence and impact of maternal GBS colonization and invasive GBS disease.Methods: A single center historical cohort study of all births between 2003 and 2015 was performed. Data was collected via electronic health record abstraction using an institutional specific tool. Descriptive statistics were performed regarding GBS status. Inferential statistics were performed comparing risk of adverse pregnancy outcomes in cohorts with and without GBS colonization as well as cohorts with GBS colonization and invasive GBS disease.Results: A total of 60,029 deliveries were included for analysis. Overall, 21.6% of the population was GBS colonized and 0.1% had invasive GBS disease. GBS colonization was associated with younger maternal age, Black race, non-Hispanic ethnicity, chronic hypertension, preexisting diabetes, and tobacco use (p