Sweepstakes reproductive success via pervasive and recurrent selective sweeps
Sweepstakes reproductive success via pervasive and recurrent selective sweeps
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DOI：
10.1101/2022.05.29.493887
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发表时间：
2022-12
期刊：
影响因子：
7.7
通讯作者：
E. Árnason;Jere Koskela;Katrín Halldórsdóttir;Bjarki Eldon
中科院分区：
文献类型：
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作者：
E. Árnason;Jere Koskela;Katrín Halldórsdóttir;Bjarki Eldon
以高早期死亡率为特征的高繁殖力自然种群比比皆是，但我们对其补充动态的了解还很初级。这种知识差距对我们对遗传变异、种群连通性、当地适应和高繁殖力种群的恢复能力的理解具有影响。抽奖繁殖成功的概念假定个体繁殖输出存在相当大的差异和偏差，是理解个体繁殖成功分布的关键。然而，仍然需要确定高繁殖力生物是否通过抽奖繁殖，如果是的话，中性抽奖和选择性抽奖的相对作用。在这里，我们使用基于联合的种群基因组数据统计分析来表明，选择性抽奖可能解释了高产大西洋鳕鱼的招募动态。我们表明，Kingman 合并（无抽奖建模）和 Xi-Beta 合并（随机抽奖建模），包括复杂的人口统计和背景选择，无法为数据提供足够的拟合。杜雷特-施魏因斯贝格合并模型提供了更大的解释力，其中选择性扫描是由新突变的反复和普遍选择性扫描产生的。我们的结果表明，抽奖繁殖和多重合并合并模型对于理解高繁殖力自然种群的遗传多样性是相关且必要的。这些发现对于了解鱼类种群的补充变异和高繁殖力生物体的一般进化基因组学具有根本意义。
Highly fecund natural populations characterized by high early mortality abound, yet our knowledge about their recruitment dynamics is somewhat rudimentary. This knowledge gap has implications for our understanding of genetic variation, population connectivity, local adaptation, and the resilience of highly fecund populations. The concept of sweepstakes reproductive success, which posits a considerable variance and skew in individual reproductive output, is key to understanding the distribution of individual reproductive success. However, it still needs to be determined whether highly fecund organisms reproduce through sweepstakes and, if they do, the relative roles of neutral and selective sweepstakes. Here we use coalescent-based statistical analysis of population genomic data to show that selective sweepstakes likely explain recruitment dynamics in the highly fecund Atlantic cod. We show that the Kingman coalescent (modeling no sweepstakes) and the Xi-Beta coalescent (modeling random sweepstakes), including complex demography and background selection, do not provide an adequate fit for the data. The Durrett-Schweinsberg coalescent, in which selective sweepstakes result from recurrent and pervasive selective sweeps of new mutations, offers greater explanatory power. Our results show that models of sweepstakes reproduction and multiple-merger coalescents are relevant and necessary for understanding genetic diversity in highly fecund natural populations. These findings have fundamental implications for understanding the recruitment variation of fish stocks and general evolutionary genomics of high-fecundity organisms.