Traffic-related air pollution and respiratory health during the first 2 yrs of life
Traffic-related air pollution and respiratory health during the first 2 yrs of life
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DOI：
10.1183/09031936.02.01182001
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发表时间：
2002-04-01
影响因子：
24.3
通讯作者：
Heinrich, J
中科院分区：
文献类型：
--
作者：
Gehring, U;Cyrys, J;Heinrich, J
作为一项关于交通相关空气污染对儿童哮喘影响的国际合作研究（TRAPCA）的一部分，研究人员分析了长期暴露于空气动力学直径50%截止值为2.5 μ m （PM2.5）、PM2.5吸光度和二氧化氮（NO2）的颗粒对健康的影响。TRAPCA研究的德国部分使用了两个正在进行的出生队列研究（德国婴儿营养干预计划（GIN I）和生活方式相关因素对人类免疫系统和儿童过敏发展的影响（LISA））的亚群数据，该研究位于慕尼黑市。基于地理信息系统（GIS）的暴露模型用于估计1756名婴儿出生地址与交通有关的空气污染物。采用Logistic回归分析可能的健康影响，并对潜在的混杂因素进行校正。PM2.5、PM2.5吸光度和二氧化氮的估计暴露范围为11.9 ~ 21.9微克。M (-3), 1.38-4.39x10(-5) M(-1), 19.5-66.9马克杯。(3)。这些污染物与无感染咳嗽(比值比（OR）（95%可信区间（CI）分别为1.34（1.11-1.61）、1.32（1.10-1.59）和1.40(1.12-1.75)）和第一年夜间干咳（OR （95% Cl）分别为1.31（1.07-1.60）、1.27（1.04-1.55）和1.36(1.07-1.74)）之间存在显著关联。在生命的第二年，这些影响减弱了。有迹象表明，与交通有关的空气污染与咳嗽症状之间存在关联。由于婴儿的年龄非常小，因此对哮喘的发展得出明确的结论还为时过早。
As part of an international collaborative study on the impact of Traffic-Related Air Pollution on Childhood Asthma (TRAPCA), the health effects associated with long-term exposure to particles with a 50% cut-off aerodynamic diameter of 2.5 mum (PM2.5), PM2.5 absorbance, and nitrogen dioxide (NO2) were analysed.The German part of the TRAPCA study used data from subpopulations of two ongoing birth cohort studies (German Infant Nutrition Intervention Programme (GIN I) and Influences of Lifestyle Related Factors on the Human Immune System and Development of Allergies in Children (LISA)) based in the city of Munich. Geographic information systems (GIS)-based exposure modelling was used to estimate traffic-related air pollutants at the birth addresses of 1,756 infants. Logistic regression was used to analyse possible health effects and potential confounding factors were adjusted for.The ranges in estimated exposures to PM2.5, PM2.5 absorbance, and NO2 were 11.9-21.9 mug.m(-3), 1.38-4.39x10(-5) m(-1), and 19.5-66.9 mug.m(3), respectively. Significant associations between these pollutants and cough without infection (odds ratio (OR) (95% confidence interval (CI): 1.34 (1.11-1.61), 1.32 (1.10-1.59), and 1.40 (1.12-1.75), respectively) and dry cough at night (OR (95% Cl): 1.31 (1.07-1.60), 1.27 (1.04-1.55), and 1.36 (1.07-1.74), respectively) in the first year of life were found. In the second year of life, these effects were attenuated.There was some indication of an association between traffic-related air pollution and symptoms of cough. Due to the very young age of the infants, it was too early to draw definitive conclusions from this for the development of asthma.