Nanotechnology-based strategies against SARS-CoV-2 variants
Nanotechnology-based strategies against SARS-CoV-2 variants
复制标题
DOI：
10.1038/s41565-022-01174-5
复制
发表时间：
2022-08-18
影响因子：
38.3
通讯作者：
Tao, Wei
中科院分区：
文献类型：
--
作者：
Huang, Xiangang;Kon, Edo;Tao, Wei
这一观点强调了纳米技术在应对新的SARS-CoV-2变种的崛起中可能发挥的作用。严重急性呼吸系统综合征冠状病毒2（SARS-CoV-2）已经感染了全球超过5亿人（截至2022年5月），造成了2019冠状病毒病（COVID-19）大流行。纳米技术在抗击SARS-CoV-2的各个方面都发挥了关键作用，其中两种基于纳米技术的高效信使RNA疫苗的成功开发最为深远。尽管mRNA疫苗对最初的SARS-CoV-2毒株具有显着的疗效，但迅速结束这一大流行的希望已被新出现的SARS-CoV-2变体所抑制，这些变体带来了几次新的大流行浪潮。因此，应该提出新的策略来解决现有和新出现的SARS-CoV-2变体所带来的危机。在这里，我们从生物学和免疫学的角度讨论了SARS-CoV-2的变种，以及合理设计和开发新的和潜在的基于纳米技术的策略，以打击现有的和未来可能的SARS-CoV-2变种。从这场对抗SARS-CoV-2变种的战斗中吸取的教训和制定的设计策略也可以激发创新，开发基于纳米技术的战略，以应对其他全球传染病及其未来的变种。
This Perspective highlights the role that nanotechnology might play in tackling the rise of new SARS-CoV-2 variants.Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has already infected more than 500 million people globally (as of May 2022), creating the coronavirus disease 2019 (COVID-19) pandemic. Nanotechnology has played a pivotal role in the fight against SARS-CoV-2 in various aspects, with the successful development of the two highly effective nanotechnology-based messenger RNA vaccines being the most profound. Despite the remarkable efficacy of mRNA vaccines against the original SARS-CoV-2 strain, hopes for quickly ending this pandemic have been dampened by the emerging SARS-CoV-2 variants, which have brought several new pandemic waves. Thus, novel strategies should be proposed to tackle the crisis presented by existing and emerging SARS-CoV-2 variants. Here, we discuss the SARS-CoV-2 variants from biological and immunological perspectives, and the rational design and development of novel and potential nanotechnology-based strategies to combat existing and possible future SARS-CoV-2 variants. The lessons learnt and design strategies developed from this battle against SARS-CoV-2 variants could also inspire innovation in the development of nanotechnology-based strategies for tackling other global infectious diseases and their future variants.