Exercise Therapy in Type 2 Diabetes Is daily exercise required to optimize glycemic control?
Exercise Therapy in Type 2 Diabetes Is daily exercise required to optimize glycemic control?
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DOI：
10.2337/dc11-2112
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发表时间：
2012-05-01
期刊：
影响因子：
16.2
通讯作者：
van Loon, Luc J. C.
中科院分区：
文献类型：
--
作者：
van Dijk, Jan-Willeni;Tummers, Kyra;van Loon, Luc J. C.
目的--鉴于运动引起的胰岛素敏感性改善的暂时性，人们推测，日常运动更倾向于最大限度地发挥运动对血糖控制的好处。研究设计与方法：30例2型糖尿病患者(年龄60+/-1岁，BMI 30.4+/-0.7 kg/m(2)，HbA(1c)7.2+/-0.2%)参加了随机交叉试验。受试者在严格的饮食标准下进行了三次为期3天的研究，其他情况下都是自由生活。血糖稳态通过连续监测超过48小时的血糖来评估，在此期间，受试者不进行运动(对照组)或60min的骑车运动(50%最大工作负荷)，分配为每隔一天进行一次单次运动或每天进行30min运动。每天或隔日运动时，每天运动时间由7：40+/-1：00h：min(32+/-4%)减少到5：46+/-0：58和5：51+/-0：47h：min，分别占运动时间的24+/-4和24+/-3%(P<；0.001)。每天锻炼和隔天锻炼的影响没有差异。结论在2型糖尿病患者中，30分钟的短时间中等强度耐力型锻炼可以显著降低随后一天的高血糖发生率。当总工作量相匹配时，与隔天锻炼相比，每天锻炼并不能进一步改善日常血糖。
OBJECTIVE-Given the transient nature of exercise-induced improvements in insulin sensitivity, it has been speculated that daily exercise is preferred to maximize the benefits of exercise for glycemic control. The current study investigates the impact of daily exercise versus exercise performed every other day on glycemic control in type 2 diabetic patients.RESEARCH DESIGN AND METHODS-Thirty type 2 diabetic patients (age 60 +/- 1 years, BMI 30.4 +/- 0.7 kg/m(2), and HbA(1c) 7.2 +/- 0.2%) participated in a randomized crossover experiment. Subjects were studied on three occasions for 3 days under strict dietary standardization but otherwise free-living conditions. Blood glucose homeostasis was assessed by continuous glucose monitoring over 48 h during which subjects performed no exercise (control) or 60 min of cycling exercise (50% maximal workload capacity) distributed either as a single session performed every other day or as 30 min of exercise performed daily.RESULTS-The prevalence of hyperglycemia (blood glucose >10 mmol/L) was reduced from 7:40 +/- 1:00 h:min per day (32 +/- 4% of the time) to 5:46 +/- 0:58 and 5:51 +/- 0:47 h:min per day, representing 24 +/- 4 and 24 +/- 3% of the time, when exercise was performed either daily or every other day, respectively (P < 0.001 for both treatments). No differences were observed between the impact of daily exercise and exercise performed every other day.CONCLUSIONS A short 30-min session of moderate-intensity endurance-type exercise substantially reduces the prevalence of hyperglycemia throughout the subsequent day in type 2 diabetic patients. When total work is being matched, daily exercise does not further improve daily glycemia compared with exercise performed every other day.