Effect of Calcium and Phosphate on Compositional Conversion from Dicalcium Hydrogen Phosphate Dihydrate Blocks to Octacalcium Phosphate Blocks
Effect of Calcium and Phosphate on Compositional Conversion from Dicalcium Hydrogen Phosphate Dihydrate Blocks to Octacalcium Phosphate Blocks
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DOI：
10.3390/cryst8050222
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发表时间：
2018-05-01
期刊：
影响因子：
2.7
通讯作者：
Ishikawa, Kunio
中科院分区：
文献类型：
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作者：
Sugiura, Yuki;Ishikawa, Kunio
磷酸八钙（OCP）作为人工骨替代品因其优异的骨传导和骨替代性能而备受关注。尽管大量研究调查了 OCP 粉末的制造，但对 OCP 块制造的研究却很少。因此，在本研究中，研究了在 pH 6 调节的乙酸盐缓冲溶液中在 70 摄氏度下优化二水磷酸氢二钙 (DCPD) 块作为 OCP 块制造前体的可行性。当DCPD块体浸入醋酸盐缓冲液中时，该块体部分转化为OCP，并含有大量无水磷酸氢二钙（DCPA），并且其宏观结构保持不变。当 DCPD 块浸入含 Ca 溶液中时，DCPA 将其主要转化为羟基磷灰石 (HAp)。另一方面，当DCPD嵌段浸入含PO4的溶液中时，该嵌段转化为OCP，并且其宏观结构保持不变。换句话说，Ca/P摩尔比低于1.0的PO4诱导的磷酸钙可能代表通过溶解-沉淀反应从DCPD嵌段到OCP嵌段的组成转变过程中的中间相。
Octacalcium phosphate (OCP) has attracted much attention as an artificial bone substitute because of its excellent osteoconductive and bone replacement properties. Although numerous studies have investigated OCP powder fabrication, there are only a few studies on OCP block fabrication. Therefore, in this study, the feasibility of optimizing dicalcium hydrogen phosphate dihydrate (DCPD) blocks, as a precursor for OCP block fabrication, under a pH 6 adjusted acetate buffer solution at 70 degrees C for 2 days was investigated. When a DCPD block was immersed in acetate buffer, the block was partially converted to OCP, with a large amount of dicalcium hydrogen phosphate anhydrate (DCPA), and its macroscopic structure was maintained. When the DCPD block was immersed in a Ca-containing solution, it was converted to mainly hydroxyapatite (HAp) with DCPA. On the other hand, when the DCPD block was immersed in a PO4-containing solution, the block was converted to OCP, and its macroscopic structure was maintained. In other words, the PO4-induced calcium phosphate with a Ca/P molar ratio lower than 1.0 may represent an intermediate phase during the compositional transformation from a DCPD block to an OCP block through the dissolution-precipitation reaction.