Efficacy of liver parenchymal enhancement and liver volume to standard liver volume ratio on Gd-EOB-DTPA-enhanced MRI for estimation of liver function
Efficacy of liver parenchymal enhancement and liver volume to standard liver volume ratio on Gd-EOB-DTPA-enhanced MRI for estimation of liver function
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DOI：
10.1007/s00330-013-3086-5
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发表时间：
2014-04-01
影响因子：
5.9
通讯作者：
Nakajo, Masayuki
中科院分区：
文献类型：
--
作者：
Yoneyama, Tomohide;Fukukura, Yoshihiko;Nakajo, Masayuki
我们的目的是开发和评估结合肝脏增强和肝脏体积与标准肝脏体积 (LV/SLV) 比率的肝功能指数对乙氧基苄基二亚乙基三胺五乙酸钆 (Gd-EOB-DTPA) 增强 MRI 的疗效。总共，111 名患者在 Gd-EOB-DTPA 给药前和给药后 20 分钟接受了 Gd-EOB-DTPA 增强 MRI，包括 T1 映射。我们计算了以下基于Gd-EOB-DTPA增强MRI的肝功能指标：肝脏相对增强、肝脾比校正增强、LSC_N20、肝肌比增加率、肝脏T1弛豫时间减少率、肝脏Delta R1和K（Hep）；该指数乘以 LV/SLV 比率。我们通过 Pearson 相关分析，计算了吲哚菁绿 (ICG) 清除率与基于 Gd-EOB-DTPA 增强 MRI 的肝功能指数乘以 LV/SLV 比值之间的相关性。所有基于 Gd-EOB-DTPA 增强 MRI 的肝功能指数与 ICG 清除率之间均存在显着相关性（r = -0.354 至 -0.574，P < 0.001）。所有基于 Gd-EOB-DTPA 增强 MRI 的肝功能指数乘以 LV/SLV 比值（r = -0.394 至 -0.700，P < 0.001）与 ICG 清除率的相关性比未乘以 LV/SLV 比值的指数更强。结合肝脏增强和 LV/SLV 比值的 Gd-EOB-DTPA 增强 MRI 肝功能指数可以更可靠地估计肝脏a欧元分 Gd-EOB-DTPA 增强 MRI 可用于评估肝功能。a欧元分 Gd-EOB-DTPA 增强 MRI 上的肝脏增强与吲哚菁绿 (ICG) 清除率相关。a欧元分 肝脏体积与标准肝脏体积 (LV/SLV) 的比率与 ICG 清除率相关。a欧元分 肝脏增强和 LV/SLV 比率有助于估计肝功能。
We aimed to develop and assess the efficacy of a liver function index that combines liver enhancement and liver volume to standard liver volume (LV/SLV) ratio on gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd-EOB-DTPA)-enhanced MRI.In all, 111 patients underwent a Gd-EOB-DTPA-enhanced MRI, including T1 mapping, before and 20 min after Gd-EOB-DTPA administration. We calculated the following Gd-EOB-DTPA-enhanced MRI-based liver function indices: relative enhancement of the liver, corrected enhancement of the liver-to-spleen ratio, LSC_N20, increase rate of the liver-to-muscle ratio, reduction rate of T1 relaxation time of the liver, Delta R1 of the liver and K (Hep); the indices were multiplied by the LV/SLV ratio. We calculated the correlations between an indocyanine green (ICG) clearance and the Gd-EOB-DTPA-enhanced MRI-based liver function indices multiplied by the LV/SLV ratio, by using Pearson correlation analysis.There were significant correlations between all Gd-EOB-DTPA-enhanced MRI-based liver function indices and ICG clearance (r = -0.354 to -0.574, P < 0.001). All Gd-EOB-DTPA-enhanced MRI-based liver function indices multiplied by the LV/SLV ratio (r = -0.394 to -0.700, P < 0.001) were more strongly correlated with the ICG clearance than those without multiplication by the LV/SLV ratio.Gd-EOB-DTPA-enhanced MRI-based liver function indices that combine liver enhancement and the LV/SLV ratio may more reliably estimate liver function.aEuro cent Gd-EOB-DTPA-enhanced MRI is useful for assessing liver function.aEuro cent Liver enhancement on Gd-EOB-DTPA-enhanced MRI correlates with indocyanine green (ICG) clearance.aEuro cent Liver volume to standard liver volume (LV/SLV) ratio correlates with ICG clearance.aEuro cent Liver enhancement and LV/SLV ratio help to estimate liver function.