Flavonoid metabolism: the synthesis of phenolic glucuronides and sulfates as candidate metabolites for bioactivity studies of dietary flavonoids
Flavonoid metabolism: the synthesis of phenolic glucuronides and sulfates as candidate metabolites for bioactivity studies of dietary flavonoids
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DOI：
10.1016/j.tet.2012.03.100
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发表时间：
2012-06-03
期刊：
影响因子：
2.1
通讯作者：
O'Hagan, David
中科院分区：
文献类型：
--
作者：
Zhang, Qingzhi;Raheem, K. Saki;O'Hagan, David
流行病学研究表明，摄入类黄酮与患冠心病的风险呈负相关，但导致其生物活性的机制仍存在争议。基于大多数黄酮类化合物快速而广泛的代谢，它们对健康的影响很可能是由于其代谢物的生物活性所致。然而，缺乏商业上可用的化合物/标准阻碍了代谢物生物活性的研究，并导致对非生理相关前体/母体结构的关注。本文详细介绍了一系列酚类葡萄糖醛酸苷1a-e和硫酸盐2a-e衍生物的合成，作为代谢谱研究和类黄酮类生物活性研究的参考化合物。(C)爱思唯尔有限公司出版的2012年。
Epidemiological studies indicate that flavonoid intake is inversely associated with the risk of coronary heart disease, yet the mechanisms responsible for their bioactivity are still a matter of debate. Based on the rapid and extensive metabolism of most flavonoids, their health effects most likely result from the biological activity of their metabolites. However, a lack of commercially available compounds/standards has prevented the study of metabolite bioactivity and resulted in a focus on non-physiologically relevant precursor/parent structures. This paper details the synthesis of a series of phenolic glucuronide 1a-e and sulfate 2a-e derivates as candidate metabolites for use as reference compounds in metabolic profiling studies and for the exploration of flavonoid bioactivity. (C) 2012 Published by Elsevier Ltd.