Ectopic expression of homeodomain protein CDX2 in intestinal metaplasia and carcinomas of the stomach
Ectopic expression of homeodomain protein CDX2 in intestinal metaplasia and carcinomas of the stomach
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DOI：
10.1016/s0304-3835(01)00753-4
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发表时间：
2002-02-08
期刊：
影响因子：
9.7
通讯作者：
Yuasa, Y
中科院分区：
文献类型：
--
作者：
Bai, YQ;Yamamoto, H;Yuasa, Y
CDX2和CDX1同源盒基因在胃癌发生中的作用尚不清楚。应用免疫组织化学方法研究了CDX2/1在69例胃癌及肠化生组织中的表达。CDX2/1在48例IM中异位过表达41例(85%)，52例IM中47例(90%)过表达。CDX2/1在69例胃癌中的阳性表达分别为38例(55%)和51例(74%)。CDX2的表达与胃癌的组织学类型独立相关，但与CDX1的表达无关，肠型(分化型)的CDX2表达高于弥漫型(未分化型)。我们的结果提示CDX2和CDX1可能在IM的形成和胃癌的发生中起作用。(C)2002爱思唯尔科学爱尔兰有限公司。保留所有权利。
The roles of CDX2 and CDX1 homeobox genes during gastric carcinogenesis remain poorly defined. We have studied the expression of CDX2/1 in gastric cancers and intestinal metaplasia (IM) of 69 gastric carcinoma patients by immunohistochemistry. CDX2/1 were shown to be ectopically overexpressed in IM in 41 (85%) of 48, and 47 (90%) of 52 cases, respectively. The expression of CDX2/1 was detected in 38 (55%) and 51 (74%) of the 69 gastric carcinomas, respectively. The histological type of the gastric carcinomas was independently associated with CDX2 expression, but not with that of CDX1, with higher CDX2 expression in intestinal type (differentiated type) than in diffuse type (undifferentiated type) gastric carcinomas. Our results thus suggest that CDX2 and CDX1 may play a role during IM formation and gastric carcinogenesis. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.