Magnetic resonance imaging techniques to monitor short term evolution of multiple sclerosis and to use in preliminary trials.
Magnetic resonance imaging techniques to monitor short term evolution of multiple sclerosis and to use in preliminary trials.
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磁共振成像技术可监测多发性硬化症的短期演变并用于初步试验。
DOI：
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发表时间：
1998
期刊：
影响因子：
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通讯作者：
J. Frank
中科院分区：
文献类型：
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作者：
D. Miller;J. Frank
短期系列磁共振成像（MRI）研究为多发性硬化症的自然史提供了重要的新见解，并为初步评估治疗效果提供了一个很好的工具。在早期复发缓解型和继发性进展型多发性硬化症中，每月T2加权和钆增强扫描平均显示每次临床复发约10个新的或增强的病变。这种方法在很大程度上依赖于血脑屏障破坏的急性炎症MRI活动的检测-由于其对长期残疾的重要性仍然不确定，目前这些方法不应用作治疗结果的最终评估。
Short term serial magnetic resonance imaging (MRI) studies have provided major new insights into the natural history of multiple sclerosis, and are providing an excellent tool for preliminary assessment of therapeutic effect. In early relapsing-remitting and secondary progressive multiple sclerosis, monthly T2-weighted and gadolinium enhanced scanning discloses, on average, about 10 new or enhancing lesions for each clinical relapse. This approach relies largely on the detection of acute inflammatory MRI activity with blood-brain barrier break down--as the importance of this for long term disability remains uncertain, these methods for the present should not be used as the definitive assessment of treatment outcome.