Sex-associated differences in the modulation of vascular risk in patients with asymptomatic carotid stenosis
Sex-associated differences in the modulation of vascular risk in patients with asymptomatic carotid stenosis
复制标题
DOI：
10.1038/jcbfm.2014.248
复制
发表时间：
2015-04-01
影响因子：
6.3
通讯作者：
Silvestrini, Mauro
中科院分区：
文献类型：
--
作者：
Buratti, Laura;Balestrini, Simona;Silvestrini, Mauro
在这项研究中，我们旨在确定无症状颈内动脉(ICA)狭窄患者中不同性别相关卒中风险的决定因素。总体而言，492名女性(44.4%)和617名男性(55.6%)患有单侧。对60%无症状颈内动脉狭窄患者进行前瞻性评估，中位随访时间为37个月(四分位数范围为26至43个月)。研究对象包括血管风险概况、斑块特征、狭窄进展和颈总动脉内中膜厚度。结果以颈内动脉狭窄同侧发生缺血性卒中为指标。心肌梗死、对侧中风和短暂性脑缺血发作被认为是相互竞争的事件。在整个随访期内，同侧卒中的发生率为0.16%，女性为0.09%(95%可信区间为0.05~0.15)，男性为0.22%(95%CI为0.17~0.29)(对数等级检验，P
In this study, we aimed to identify determinants of the different sex-related stroke risk in subjects with asymptomatic internal carotid artery (ICA) stenosis. In all, 492 women (44.4%) and 617 men (55.6%), with unilateral. >= 60% asymptomatic ICA stenosis, were prospectively evaluated with a median follow-up of 37 months (interquartile range, 26 to 43). Vascular risk profile, plaque characteristics, stenosis progression, and common carotid artery intima-media thickness were investigated. Outcome measure was the occurrence of ischemic stroke ipsilateral to ICA stenosis. Myocardial infarction, contralateral stroke and transient ischemic attack were considered as competing events. The incidence rate of ipsilateral stroke over the entire follow-up period was 0.16%: 0.09% (95% confidence interval (CI) 0.05 to 0.15) in women and 0.22% (95% CI 0.17 to 0.29) in men (log-rank test, P