Genetic polymorphisms in IL-2, IL-10, TGF-β1, and IL-2RB and acute rejection in renal transplant patients
Genetic polymorphisms in IL-2, IL-10, TGF-β1, and IL-2RB and acute rejection in renal transplant patients
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DOI：
10.1111/ctr.12346
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发表时间：
2014-06-01
影响因子：
2.1
通讯作者：
Van Gelder, Teun
中科院分区：
文献类型：
--
作者：
Chen, Zhigang;Bouamar, Rachida;Van Gelder, Teun
急性排斥反应（AR）仍然是肾移植的一个问题。细胞因子是所有免疫和炎症反应的诱导和效应阶段的关键介质。细胞因子及其受体的单核苷酸多态性（SNP）可能与AR有关。我们研究了325例肾移植患者在移植后第一年内AR与编码IL-2（-330 G>T）、IL-10（-592 C>A和-1082 G>A）、TGF-1（915 G>C）和IL-2 RB（rs 228942 C>A和rs 228953 C>T）的基因中SNPs的关系。AR的总发生率为15.4%。在多变量分析中，只有使用诱导治疗与AR相关（比值比1.9; 95%置信区间1.1-3.7; p=0.04）。研究的SNPs和AR之间没有观察到统计学显著相关性。研究的细胞因子及其受体中的SNP与AR的风险无关。对患者进行这些SNP的基因分型不太可能帮助临床医生调整个体患者的免疫抑制治疗。
Acute rejection (AR) remains a concern for kidney transplantation. Cytokines are key mediators in the induction and effector phases of all immune and inflammatory responses. Single nucleotide polymorphisms (SNPs) in cytokines and their receptors may relate to AR. We investigated the relation between AR and SNPs in the genes encoding for IL-2(-330G>T), IL-10(-592C>A and -1082G>A), TGF-1(915G>C), and IL-2RB(rs228942 C>A and rs228953 C>T) in 325 renal transplant patients during the first year after transplantation. The overall incidence of AR was 15.4%. In multivariate analysis, only the use of induction therapy was correlated with AR (odds ratio 1.9; 95% confidence interval 1.1-3.7; p=0.04). No statistically significant associations between the SNPs studied and AR were observed. SNPs in the investigated cytokines and their receptors were not associated with the risk of AR. Genotyping patients for these SNPs is unlikely to aid the clinician in adjusting the immunosuppressive therapy for individual patients.