Time in bed, sleep quality and associations with cardiometabolic markers in children: the Prevention and Incidence of Asthma and Mite Allergy birth cohort study
Time in bed, sleep quality and associations with cardiometabolic markers in children: the Prevention and Incidence of Asthma and Mite Allergy birth cohort study
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DOI：
10.1111/jsr.12087
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发表时间：
2014-02-01
影响因子：
4.4
通讯作者：
Wijga, Alet H.
中科院分区：
文献类型：
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作者：
Berentzen, Nina E.;Smit, Henriette A.;Wijga, Alet H.
我们调查了儿童卧床时间和多重睡眠质量特征与心脏代谢指标的关系。对1996年至1997年在荷兰开始的基于人群的前瞻性出生队列研究哮喘和尘螨过敏的预防和发病率研究的数据进行了分析。总共有1481名11-12岁的儿童完成了一份问卷(包括有关睡眠的问题)，并接受了体检。我们测量了体重指数、腰围、总密度和高密度脂蛋白胆固醇、血压和糖化血红蛋白。结果表明，女孩的一些睡眠特征与人体测量指标(身体质量指数、腰围)和胆固醇有关。卧床时间长(11~12.5h)的女生与卧床时间在10~10.5h的女生相比，体重指数z得分低0.16(95%可信区间-0.31；-0.01)，腰围小0.99 cm(95%可信区间-2.01；-0.13)。晚睡早起女孩的总胆固醇(95%可信区间0.01；0.31)和高密度脂蛋白胆固醇(95%可信区间0.01；0.14)比早睡早起女孩高0.16 mm(95%可信区间0.01；0.14)。有夜间醒来的女孩的总胆固醇比没有夜间醒来的女孩高0.14 mm(95%可信区间0.03；0.25)。与不困倦的女孩相比，每周感觉困倦/疲倦的女孩的高密度脂蛋白胆固醇降低0.10 mm(95%可信区间-0.16；-0.04)，总胆固醇/高密度脂蛋白胆固醇比率高0.17 mm(95%可信区间0.02；0.32)。没有发现与男孩有关的联系。睡眠特征与血压和糖化血红蛋白无关，而且这些联系在女孩中的影响规模很小。因此，我们认为，提出改善睡眠可以降低儿童时期的心血管风险还为时过早。
We investigated associations of time in bed and multiple sleep quality characteristics with cardiometabolic markers in children. Data from the prevention and incidence of asthma and mite allergy study, a population-based prospective birth-cohort study started in 1996-1997 in the Netherlands, were analysed. In total 1481 children aged 11-12years completed a questionnaire (including questions on sleep) and underwent a medical examination. We measured body mass index, waist circumference, total- and high-density lipoprotein cholesterol, blood pressure and glycated haemoglobin. Results showed that in girls, some sleep characteristics were related to anthropometrics (body mass index, waist circumference) and cholesterol. Girls who had a long time in bed (11-12.5h) had 0.16 lower body mass index z-score (95% confidence interval -0.31; -0.01) and 0.99cm smaller waist circumference (95% confidence interval -2.01; -0.13) compared with girls who spent 10-10.5h in bed. Girls who went to bed late and rose early had 0.16mm higher total cholesterol (95% confidence interval 0.01; 0.31) and 0.08mm higher high-density lipoprotein cholesterol (95% confidence interval 0.01; 0.14) than early to bed/early rise' girls. Girls with night-time awakenings had 0.14mm higher total cholesterol (95% confidence interval 0.03; 0.25) than girls without night-time awakenings. Girls who felt sleepy/tired 1day per week had 0.10mm lower high-density lipoprotein cholesterol (95% confidence interval -0.16; -0.04) and 0.17mm higher total cholesterol/high-density lipoprotein cholesterol ratio (95% confidence interval 0.02; 0.32) than girls who did not feel sleepy. No associations were found for boys. Sleep characteristics were not related to blood pressure and glycated haemoglobin, and effect sizes of the associations in girls were small. Therefore, we consider it premature to propose that improved sleep could reduce cardiovascular risk during childhood.