Exercise-induced changes in brain glucose and serotonin revealed by microdialysis in rat hippocampus:: effect of glucose supplementation
Exercise-induced changes in brain glucose and serotonin revealed by microdialysis in rat hippocampus:: effect of glucose supplementation
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DOI：
10.1046/j.1365-201x.2001.00859.x
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发表时间：
2001-10-01
期刊：
影响因子：
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通讯作者：
Guezennec, CY
中科院分区：
文献类型：
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作者：
Béquet, F;Gomez-Merino, D;Guezennec, CY
本研究的目的是评估体育锻炼后海马细胞外葡萄糖的变化，并确定葡萄糖补充的影响。同时，我们观察了血清素的变化，以研究运动过程中葡萄糖与血清素的关系。葡萄糖和血清素均通过微透析进行评估。运动诱导细胞外葡萄糖水平在运动期间比基线升高至121.1 +/- 3.0% (P < 0.001)，然后在恢复期间降至基线。血清素在运动前90 min随血糖变化而变化，但在恢复过程中表现出不同的变化规律，在恢复30 min后，血清素升高至最高值129.9 +/- 7.0% (P < 0.001)；在运动和恢复过程中，当输注15%葡萄糖溶液（10 μ l min(-1)）时，血糖浓度升高，但细胞外脑葡萄糖浓度下降，在恢复90 min后最低达到73.3 +/- 4.6% （P < 0.001）。血清素始终是脑葡萄糖的镜像反映，恢复90 min后血清素最高升高142.0 +/- 6.9% （P < 0.001）。这些结果表明，运动引起脑葡萄糖和5-羟色胺（5-HT）水平的变化，葡萄糖输注显著改变了这些变化。考虑到大脑5-羟色胺对中枢疲劳的影响，他们认为，如果在运动前和运动中补充葡萄糖，无疑会因为其周围的积极作用而提高表现，那么它会对运动结束后的恢复质量产生负面影响。
The aim of this study was to assess extracellular glucose changes in hippocampus in response to physical exercise and to determine the influence of glucose supplementation. In the same time, we have observed the changes in serotonin, in order to study the relationship between glucose and serotonin during exercise. Both glucose and serotonin were assessed using microdialysis. Exercise induced an increase In extracellular glucose levels over baseline during exercise to 121.1 +/- 3.0% (P < 0.001), then a decrease to baseline during recovery. The serotonin followed glucose changes during the first 90 min of exercise, but followed a different pattern during recovery, increasing to a maximum of 129.9 +/- 7.0% after 30 min of recovery (P < 0.001), When a 15% glucose solution was infused (10 muL min(-1)) during exercise and recovery, blood glucose concentration was increased, but extracellular brain glucose decreased to reach a minimum of 73.3 +/- 4.6% after 90 min of recovery (P < 0.001). Serotonin was always the mirror-reflect of cerebral glucose, with a maximum increase of 142.0 +/- 6.9% after 90 min of recovery (P < 0.001). These results show that exercise induces changes in brain glucose and 5-hydroxytryptamine (5-HT) levels, which were dramatically modified by glucose infusion. Taking into account the implication of brain 5-HT in central fatigue, they suggest that if glucose supplementation, before and during exercise, undoubtedly increase performance because of Its peripheral positive action, it would have a negative impact on the quality of recovery after the end of the exercise.