Low intensity repetitive transcranial magnetic stimulation drives
Low intensity repetitive transcranial magnetic stimulation drives
复制标题
低强度重复经颅磁刺激驱动
DOI：
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
A. Canty
中科院分区：
文献类型：
--
作者：
A. Tang;W. Bennett;A. Bindoff;J. Collins;I. Michael;Garry;J. Summers;M. Hinder;J. Rodger;A. Canty
重复经颅磁刺激（rTMS）是一种非侵入性工具，通常用于驱动年轻成人和老年人大脑的神经可塑性。最近来自20个小鼠模型的数据表明，即使在低强度（0.12特斯拉）下，rTMS也可以驱动运动皮层中的神经元和神经胶质可塑性。然而，低强度rTMS（LI-rTMS）诱导可塑性的生理机制以及这些机制是否会随着正常衰老而改变尚不清楚。使用纵向在体内2-光子24显微镜，我们研究了LI-rTMS对运动皮层中25个锥体神经元树突棘的结构可塑性的影响，在一个单一的列车LI 26 rTMS（在年轻的成年人和老年动物）或相同的LI-rTMS列车连续27 - 4天（仅在年轻的成年动物）。我们发现，LI-rTMS改变了树突棘的损失和收益率，这取决于刺激的次数，并且LI-rTMS的单次会话在驱动年轻成年小鼠和老年小鼠的结构突触可塑性方面是有效的。据我们所知，这31个结果提供了rTMS驱动脑中突触可塑性的第一个体内证据，并揭示了结构突触可塑性是LI-rTMS 33诱导可塑性的关键机制。34
18 Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive tool commonly 19 used to drive neural plasticity in the young adult and aged brain. Recent data from 20 mouse models have shown that even at low intensities (0.12 Tesla), rTMS can drive 21 neuronal and glial plasticity in the motor cortex. However, the physiological 22 mechanisms underlying low intensity rTMS (LI-rTMS) induced plasticity and whether 23 these are altered with normal ageing are unclear. Using longitudinal in vivo 2-photon 24 microscopy, we investigated the effect of LI-rTMS on the structural plasticity of 25 pyramidal neuron dendritic spines in the motor cortex following a single train of LI26 rTMS (in young adult and aged animals) or the same LI-rTMS train administered on 27 4 consecutive days (in young adult animals only). We found that LI-rTMS altered the 28 rate of dendritic spine losses and gains, dependent on the number of stimulation 29 sessions and that a single session of LI-rTMS was effective in driving structural 30 synaptic plasticity in both young adult and aged mice. To our knowledge, these 31 results provide the first in vivo evidence that rTMS drives synaptic plasticity in the 32 brain and uncovers structural synaptic plasticity as a key mechanism of LI-rTMS 33 induced plasticity. 34
DOI：
10.3978/j.issn.2223-4292.2014.11.31
发表时间：
2015-02-01
影响因子：
2.8
作者：
Park, Kicheon;You, Jiang;Pan, Yingtian
通讯作者：
Pan, Yingtian