Upregulation of long non-coding RNA CCAT2 indicates a poor prognosis and promotes proliferation and metastasis in intrahepatic cholangiocarcinoma
Upregulation of long non-coding RNA CCAT2 indicates a poor prognosis and promotes proliferation and metastasis in intrahepatic cholangiocarcinoma
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DOI：
10.3892/mmr.2018.8518
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发表时间：
2018-04-01
影响因子：
3.4
通讯作者：
Sun, Chao
中科院分区：
文献类型：
--
作者：
Bai, Jian-Guo;Tang, Rui-Feng;Sun, Chao
肝内胆管细胞癌（IHCC）是一种侵袭性癌症，生存率低，是肝胆系统第二常见的原发性癌症。目前，IHCC发生和发展的分子机制尚不清楚。最近的证据表明，长链非编码RNA（lncRNA）在癌症的发展中起着至关重要的作用，然而，lncRNA在IHCC中的功能作用尚未得到详细研究。在本研究中，在IHCC细胞系和临床标本中观察到lncRNA结肠癌相关转录本2（CCAT2）的显著过表达。对IHCC临床病理特征和CCAT 2表达数据的统计学分析显示，CCAT 2高表达与IHCC的微血管浸润、分化程度、肿瘤（T）、淋巴结（N）、转移（M）和TNM分期相关（P
Intrahepatic cholangiocarcinoma (IHCC) is an aggressive cancer with a poor survival rate and is the second most common type of primary cancer of the hepatobiliary system. At present, the molecular mechanisms of IHCC initiation and progression remain unclear. Recent evidence has indicated that long non-coding RNAs (lncRNAs) serve a crucial role in cancer development; however, the functional role of lncRNAs in IHCC has not been investigated in detail. In the present study, a marked overexpression of lncRNA colon cancer-associated transcript 2 (CCAT2) was observed in IHCC cell lines and clinical specimens. Statistical analysis of IHCC clinicopathological characteristics and CCAT2 expression data revealed that high CCAT2 expression levels correlated with microvascular invasion, differentiation grade, tumor (T), lymph node (N), metastasis (M) and overall TNM stages of IHCC (P