Carbohydrate and Domain Architecture of an Immature Antibody Glycoform Exhibiting Enhanced Effector Functions
Carbohydrate and Domain Architecture of an Immature Antibody Glycoform Exhibiting Enhanced Effector Functions
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DOI：
10.1016/j.jmb.2009.02.033
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发表时间：
2009-04-17
影响因子：
5.6
通讯作者：
Jones, E. Yvonne
中科院分区：
文献类型：
--
作者：
Crispin, Max;Bowden, Thomas A.;Jones, E. Yvonne
抗体含有一个保守的糖基化位点，它已成为抗体效应器功能调节的靶点。一种生物合成的人IgG1中间体的晶体结构表明，糖链工程可以使Fc偏向开放构象，为受体结合做准备。(C)2009爱思唯尔有限公司。保留所有权利。
Antibodies contain a conserved glycosylation site that has emerged as a target for the modulation of antibody effector functions. The crystal structure of a biosynthetic intermediate of human IgG1, bearing immature oligomannose-type glycans and reported to display increased antibody-dependent cellular cytotoxicity, demonstrates that glycan engineering can bias the Fc to an open conformation primed for receptor binding. (C) 2009 Elsevier Ltd. All rights reserved.