Essential role of miRNAs in orchestrating the biology of the tumor microenvironment.
Essential role of miRNAs in orchestrating the biology of the tumor microenvironment.
复制标题
DOI：
10.1186/s12943-016-0525-3
复制
发表时间：
2016-05-26
期刊：
影响因子：
37.3
通讯作者：
Fabbri M
中科院分区：
文献类型：
--
作者：
Frediani JN;Fabbri M
MicroRNA（miRNAs）正在成为塑造肿瘤微环境（TME）生物学的核心参与者。它们通过调节TME不同细胞内的表达水平以及在外泌体和其他细胞外囊泡内的不同细胞群之间穿梭来实现这一目标。本文综述了miRNA在TME复杂性中的作用的最新知识，并强调了该领域的局限性和挑战。更好地了解这些迷人的小分子的作用机制将导致新的治疗武器的开发，最重要的是，改善癌症患者的临床结果。
MicroRNAs (miRNAs) are emerging as central players in shaping the biology of the Tumor Microenvironment (TME). They do so both by modulating their expression levels within the different cells of the TME and by being shuttled among different cell populations within exosomes and other extracellular vesicles. This review focuses on the state-of-the-art knowledge of the role of miRNAs in the complexity of the TME and highlights limitations and challenges in the field. A better understanding of the mechanisms of action of these fascinating micro molecules will lead to the development of new therapeutic weapons and most importantly, to an improvement in the clinical outcome of cancer patients.