The Chlamydomonas genome reveals the evolution of key animal and plant functions
The Chlamydomonas genome reveals the evolution of key animal and plant functions
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DOI：
10.1126/science.1143609
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发表时间：
2007-10-12
期刊：
影响因子：
56.9
通讯作者：
Grossman, Arthur R.
中科院分区：
文献类型：
--
作者：
Merchant, Sabeeha S.;Prochnik, Simon E.;Grossman, Arthur R.
莱茵衣藻是一种单细胞绿藻，其谱系在 10 亿多年前就从陆地植物中分化出来。它是研究基于叶绿体的光合作用以及真核鞭毛（纤毛）的结构、组装和功能的模型系统，这些鞭毛遗传自植物和动物的共同祖先，但在陆地植物中丢失了。我们对衣藻相似的 120 兆碱基核基因组进行了测序，并进行了比较系统发育分析，鉴定了编码可能与叶绿体或真核鞭毛的功能和生物发生相关的未表征蛋白质的基因。对衣藻基因组的分析增进了我们对祖先真核细胞的理解，揭示了以前未知的与光合作用和鞭毛功能相关的基因，并建立了纤毛病与鞭毛的组成和功能之间的联系。
Chlamydomonas reinhardtii is a unicellular green alga whose lineage diverged from land plants over 1 billion years ago. It is a model system for studying chloroplast-based photosynthesis, as well as the structure, assembly, and function of eukaryotic flagella (cilia), which were inherited from the common ancestor of plants and animals, but lost in land plants. We sequenced the similar to 120-megabase nuclear genome of Chlamydomonas and performed comparative phylogenomic analyses, identifying genes encoding uncharacterized proteins that are likely associated with the function and biogenesis of chloroplasts or eukaryotic flagella. Analyses of the Chlamydomonas genome advance our understanding of the ancestral eukaryotic cell, reveal previously unknown genes associated with photosynthetic and flagellar functions, and establish links between ciliopathy and the composition and function of flagella.