The first total synthesis of (±)-eremopetasidione
The first total synthesis of (±)-eremopetasidione
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DOI：
10.1021/ol000355n
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发表时间：
2001-01-25
期刊：
影响因子：
5.2
通讯作者：
Liao, CC
中科院分区：
文献类型：
--
作者：
Hsu, DS;Hsu, PY;Liao, CC
[图表]外消旋eremopetasidione（一种降倍半萜）的全合成已经以9个步骤和30%的总产率从杂酚醇（5）开始实现。掩蔽邻苯醌6与乙基乙烯基酮的Diels-Alder反应和2-硅氧基-1，5-二烯酮3的科普重排反应是关键步骤。
[GRAPHICS]The total synthesis of racemic eremopetasidione, a norsesquiterpenoid, has been achieved in nine steps and 30% overall yield starting from creosol (5). Diels-Alder reaction of masked o-benzoquinone 6 and ethyl vinyl ketone and Cope rearrangement of 2-silyloxy-1,5-dienone 3 are the key steps.