Rectal Content and Intrafractional Prostate Gland Motion Assessed by Magnetic Resonance Imaging
Rectal Content and Intrafractional Prostate Gland Motion Assessed by Magnetic Resonance Imaging
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DOI：
10.1269/jrr.10126
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发表时间：
2011-03-01
影响因子：
2
通讯作者：
Morita, Satoshi
中科院分区：
文献类型：
--
作者：
Ogino, Ichiro;Kaneko, Tetsuji;Morita, Satoshi
前列腺癌/放射治疗/MRI/分次内/直肠气体：我们评估了直肠内容物和前列腺分次内运动之间的相互关系。47例前列腺癌患者被告知要去除直肠气体，在放疗前（RT）和放疗期间通过计划CT和MRI进行成像。总扫描时间与我们的锥形束CT扫描和治疗时间相当。通过T2加权轴向MRI将直肠内容物定性评估为四个不同类别：空（E组）、气体（G组）、气体和粪便的组合（C组）和粪便（F组）。在随后的矢状电影MRI切片上确定了11个解剖学兴趣点（POI）。在E组、G组、C组和F组中，其中一个前列腺POI的位移超过3 mm的发生率分别为6.3%、40.9%、6.3%和0%，超过10%的时间（> 10%的时间超过3 mm）。除G组外。> 3 mm位移的平均概率<3%。仅G组患者在AP方向（SAP）的上级前列腺位移超过3 mm的时间超过10%，RT前为45.5%，RT期间为18.2%。通过多变量分析，仅G组患者与SAP前列腺位移的平均值和平均最大值均显著相关。多因素分析显示，G组患者与上级直肠和中层直肠宽度的标准差均数也有显著相关性。仅直肠气体患者与前列腺移位和直肠运动显著相关。
Prostate cancer/Radiotherapy/MRI/Intrafraction/Rectal gas.We evaluated the interrelationship between rectal content and intrafraction motion of the prostate. Forty seven prostate cancer patients instructed to remove their rectal gas were imaged by planning CT and MRI before radiotherapy (RT) and during RT. The total scan time was comparable to our cone-beam CT scanning and treatment times. Rectal content was qualitatively assessed into four different categories by T2-weighted axial MRI: empty (Group E), gas (Group G), combination of gas and feces (Group C), and feces (Group F). Eleven anatomic points of interest (POI) were determined on subsequent sagittal cine-MRI slices. The incidence of displacement of more than 3 mm for more than 10% of time (> 10% time over 3 mm) al. least in one of the prostate POIs in Group E was 6.3%, Group G 40.9%, Group C 6.3%, and Group F 0%, respectively. Except for Group G. the mean probability of > 3 mm displacement was < 3%. More than 10% time over 3 mm displacement of the superior prostate in the AP direction (SAP) was noted in only Group G patients and was 45.5% before RT and 18.2% during RT. Only Group G patients were significantly related to both the mean of means and the mean of maxs of prostate displacement of SAP by multivariate analysis. Group G patients were also significantly related to the mean of the standard deviation of rectum width of superior rectum and mid-rectum by multivariate analysis. Patients with rectal gas only were significantly related to prostate displacement and rectal movement.