Pathways from obesity to diabetes
Pathways from obesity to diabetes
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DOI：
10.1038/sj.ijo.0802126
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发表时间：
2002-09-01
影响因子：
4.9
通讯作者：
Golay, A
中科院分区：
文献类型：
--
作者：
Felber, JP;Golay, A
肥胖和2型糖尿病之间的关系已经被了解了几十年，最近这类疾病的重要增加代表了世界范围内的主要医学问题。一些前瞻性研究表明，胰岛素释放受损和胰岛素抵抗是2型糖尿病发展的主要因素。在肥胖中占主导地位的因素是血浆FFA的永久性升高和肌肉对脂质的主要利用，从而诱导葡萄糖摄取减少，并因此导致胰岛素抵抗。胰岛素分泌的增加似乎是一种代偿机制，对循环葡萄糖水平的增加作出反应。胰岛素分泌下降是一种晚期现象。本综述旨在分析导致人类肥胖的2型糖尿病的机制，并利用病理生理信息预防糖尿病。今天，生活方式的改变和多学科减肥计划充分证明了肥胖向糖尿病演变的部分可逆性。
The relationship between obesity and type 2 diabetes has been known for decades and the recent important increase in such diseases represents a major medical problem worldwide. Several prospective studies present both impaired insulin release and insulin resistance as the major factors for the development of type 2 diabetes. The factor that dominates in obesity is the permanent elevation of plasma FFA and the predominant utilization of lipids by the muscle inducing a diminution of glucose uptake and, therefore, insulin resistance. The rise in insulin secretion appears to be a compensatory mechanism that responds to the increased levels of circulating glucose. The fall in insulin secretion occurs as a late phenomenon. The present review aims at analysing the mechanisms that lead human obesity to type 2 diabetes and using the pathophysiological information for the prevention of diabetes. The partial reversibility of the evolution of obesity towards diabetes is well demonstrated today by lifestyle changes and multidisciplinary weight loss programs.