Triggering the interferon antiviral response through an IKK-related pathway
Triggering the interferon antiviral response through an IKK-related pathway
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DOI：
10.1126/science.1081315
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发表时间：
2003-05-16
期刊：
影响因子：
56.9
通讯作者：
Hiscott, J
中科院分区：
文献类型：
--
作者：
Sharma, S;tenOever, BR;Hiscott, J
I型干扰素表达的快速诱导是建立先天性抗病毒反应的中心事件，需要许多转录因子的协同激活。尽管激活转录因子核因子kappaB和ATF-2/c-Jun的信号通路已经得到很好的表征，但干扰素调节因子IRF-3和IRF-7的激活仍然是理解干扰素信号传导的关键缺失环节。我们在这里报告说，IkappaB激酶（IKK）相关的激酶IKK 3和TANK结合激酶1是磷酸化IRF-3和IRF-7的病毒活化激酶的组成部分。这些研究阐明了IKK相关激酶通路在触发宿主对病毒感染的抗病毒反应中的重要作用。
Rapid induction of type I interferon expression, a central event in establishing the innate antiviral response, requires cooperative activation of numerous transcription factors. Although signaling pathways that activate the transcription factors nuclear factor kappaB and ATF-2/c-Jun have been well characterized, activation of the interferon regulatory factors IRF-3 and IRF-7 has remained a critical missing link in understanding interferon signaling. We report here that the IkappaB kinase (IKK)-related kinases IKKepsilon and TANK-binding kinase 1 are components of the virus-activated kinase that phosphorylate IRF-3 and IRF-7. These studies illustrate an essential role for an IKK-related kinase pathway in triggering the host antiviral response to viral infection.