LIPASE CATALYSIS IN ORGANIC-SOLVENTS - APPLICATION TO THE SYNTHESIS OF (R)-ATENOLOL AND (S)-ATENOLOL
LIPASE CATALYSIS IN ORGANIC-SOLVENTS - APPLICATION TO THE SYNTHESIS OF (R)-ATENOLOL AND (S)-ATENOLOL
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DOI：
10.1021/jo00048a040
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发表时间：
1992-10-23
影响因子：
3.6
通讯作者：
BANERJI, AA
中科院分区：
文献类型：
--
作者：
BEVINAKATTI, HS;BANERJI, AA
Synthesis of (R)- and (S)-atenolol (1) was achieved in five steps starting from p-hydroxyphenylacetic acid. Lipase from Pseudomonas cepacia showed excellent selectivity toward kinetic resolution of key intermediates 1-[p-[(butoxycarbonyl)methyl]phenoxy]-3-chloropropan-2-ol (9) and its O-acetyl ester, 1-[p-[(butoxycarbonyl)methyl]phenoxy]-2-acetoxy-3-chloropropane (10).
