FIA-AAS determination of salicylic acid by a solid-phase reactor of copper carbonate incorporated in polyester resin beads.
FIA-AAS determination of salicylic acid by a solid-phase reactor of copper carbonate incorporated in polyester resin beads.
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DOI：
10.1016/0039-9140(95)01575-v
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发表时间：
1995-09
期刊：
影响因子：
6.1
通讯作者：
G. Rivas;J. Calatayud
中科院分区：
文献类型：
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作者：
G. Rivas;J. Calatayud
在固相反应器中，用包封在高分子材料中的碳酸铜与水杨酸反应测定水杨酸；采用火焰原子吸收法在324.8 nm处对铜离子的释放进行了监测。在水杨酸浓度4.0 ~ 75 μg ml−1范围内，校正曲线呈线性，相对标准偏差小于1.5%，采样时间为257 h−1。研究了外源化合物对水杨酸含量的影响，并将该方法应用于两种不同制剂中水杨酸含量的测定。
The determination of salicylic acid was carried out by reaction of the drug with copper carbonate entrapped in a polymeric material in a solid-phase reactor; the released cupric ions were monitored by flame atomic absorption at 324.8 nm. The calibration graph is linear over the range 4.0–75 μg ml−1of salicylic acid, with a relative standard deviation of less than 1.5% and a sample throughout of 257 h−1. The influence of foreign compounds was studied and the method was applied to the determination of salicylic acid content in two different pharmaceutical formulations.