SPECIES DIFFERENCE IN GLUCOGENIC BEHAVIOR OF BUTYRATE IN LACTATING RUMINANTS
SPECIES DIFFERENCE IN GLUCOGENIC BEHAVIOR OF BUTYRATE IN LACTATING RUMINANTS
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DOI：
10.1016/0010-406x(70)90488-3
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发表时间：
1970-01-01
期刊：
影响因子：
--
通讯作者：
BLACK, AL
中科院分区：
文献类型：
--
作者：
ANAND, RS;BLACK, AL
奶牛和山羊注射引爆剂后，持续输注NaH14CO3至7h，1h后呼吸的CO2达到恒定的比活力，2.5h后血糖达到恒定的比活力，静脉注射丙酸钠可引起奶牛和山羊的血糖浓度升高和葡萄糖相对于CO2的比活力增加。~(14)C从碳酸氢盐转移到葡萄糖的增加反映了丙酸盐注射后糖异生的增加。注射丁酸钠可引起两种动物不同的反应，山羊的血糖浓度升高幅度大于奶牛，山羊的血糖比活力急剧下降，奶牛的血糖比活力升高。山羊似乎通过增加糖原分解而对丁酸盐注射有反应。奶牛在注射丁酸盐后表现出更强的糖异生作用，最好的解释是通过增加乙酰辅酶A来增强丙酮酸羧化酶的作用，从而使丙酮酸更多地转化为草酰乙酸酯。
Cows and goats were injected with a primer dose followed by constant infusion of NaH14CO3for a period up to 7 h. A constant specific activity was reached in respired CO2after 1 h and in plasma glucose after 2.5 h. Injection of sodium propionate intravenously caused an increase in plasma glucose concentration and increased specific activity of glucose relative to CO2in both cows and goats. Increased transfer of14C from bicarbonate to glucose reflects increased gluconeogenesis after propionate injection. Injection of sodium butyrate caused different responses in the 2 species; there was a greater increase in plasma glucose concentration in goats than in cows, and in goats the specific activity of glucose decreased sharply while in cows it increased. Goats appear to respond to butyrate injection by increased glycogenolysis. Cows show increased gluconeogenesis after butyrate injection which is best explained as an effect causing greater conversion of pyruvate to oxaloacetate, presumably by enhancing pyruvate carboxylase through increase of acetyl coenzyme A.