Effect of atmospheric gas plasmas on cancer cell signaling
Effect of atmospheric gas plasmas on cancer cell signaling
复制标题
DOI：
10.1002/ijc.28323
复制
发表时间：
2014-04-01
影响因子：
6.4
通讯作者：
Ostrikov, Kostya (Ken)
中科院分区：
文献类型：
--
作者：
Ishaq, Musarat;Evans, Margaret (Meg);Ostrikov, Kostya (Ken)
癌症是最威胁生命的疾病之一，许多形式仍然被认为是不可治愈的。传统的癌症治疗有不必要的副作用，如正常细胞的死亡。一种能够准确靶向并有效杀死肿瘤细胞的疗法可以解决现有疗法的不足。与传统疗法相比，能够特异性杀死癌细胞的大气气体等离子体（AGP）提供了一种有前途的替代方法。AGP已被证明利用肿瘤特异性遗传缺陷，最近在小鼠中的试验证实了其抗肿瘤作用。AGP作用于肿瘤细胞而不是正常细胞的机制尚未完全了解。目前的文献综述表明，活性氧（ROS）产生的AGP通过损害细胞内调节因子的功能诱导癌细胞死亡。大多数癌细胞在干扰正常细胞生长途径的肿瘤抑制因子中存在缺陷。抗氧化剂/或ROS信号通路的原癌基因或肿瘤抑制因子依赖性调节可能参与AGP诱导的癌细胞死亡。正常细胞通过调节其代谢途径来减轻ROS的毒性作用。另一方面，肿瘤细胞大多数在几种调节信号通路中存在缺陷，这导致细胞内代谢平衡的丧失，从而导致细胞生长的调节。这篇综述文章评估了AGP对细胞信号激活的影响及其对探索安全有效的抗癌治疗机制的重要性。
Cancer is one of the most life-threatening diseases with many forms still regarded as incurable. The conventional cancer treatments have unwanted side effects such as the death of normal cells. A therapy that can accurately target and effectively kill tumor cells could address the inadequacies of the available therapies. Atmospheric gas plasmas (AGP) that are able to specifically kill cancerous cells offer a promising alternative approach compared to conventional therapies. AGP have been shown to exploit tumor-specific genetic defects and a recent trial in mice has confirmed its antitumor effects. The mechanism by which the AGP act on tumor cells but not normal cells is not fully understood. A review of the current literature suggests that reactive oxygen species (ROS) generated by AGP induce death of cancer cells by impairing the function of intracellular regulatory factors. The majority of cancer cells are defective in tumor suppressors that interfere normal cell growth pathways. It appears that pro-oncogene or tumor suppressor-dependent regulation of antioxidant/or ROS signaling pathways may be involved in AGP-induced cancer cell death. The toxic effects of ROS are mitigated by normal cells by adjustment of their metabolic pathways. On the other hand, tumor cells are mostly defective in several regulatory signaling pathways which lead to the loss of metabolic balance within the cells and consequently, the regulation of cell growth. This review article evaluates the impact of AGP on the activation of cellular signaling and its importance for exploring mechanisms for safe and efficient anticancer therapies.