Platination of nucleobases to enhance noncovalent recognition in protein-DNA/RNA complexes
Platination of nucleobases to enhance noncovalent recognition in protein-DNA/RNA complexes
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DOI：
10.1021/ic049086d
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发表时间：
2005-02-07
影响因子：
4.6
通讯作者：
Farrell, N
中科院分区：
文献类型：
--
作者：
Anzellotti, AI;Ma, ES;Farrell, N
荧光猝灭实验表明，核酸碱基和I-色氨酸之间的堆积相互作用显着增强后，基地协调的金属中心，如Pt（II），这种增强的生物学意义进行了讨论。
Fluorescence quenching experiments show that the stacking interaction between nucleic acid bases and I-tryptophan is enhanced significantly upon base coordination to a metal center such as Pt(II), and the biological implications of such enhancement are discussed.