Pd‐Catalyzed Asymmetric Allylic Alkylation with Nitromethane Using a Chiral Diaminophosphine Oxide: (S,Rp)‐Ph‐DIAPHOX. Enantioselective Synthesis of (R)‐Preclamol and (R)‐Baclofen.
Pd‐Catalyzed Asymmetric Allylic Alkylation with Nitromethane Using a Chiral Diaminophosphine Oxide: (S,Rp)‐Ph‐DIAPHOX. Enantioselective Synthesis of (R)‐Preclamol and (R)‐Baclofen.
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DOI：
10.1002/chin.200652029
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发表时间：
2006-09
期刊：
影响因子：
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通讯作者：
T. Nemoto;L. Jin;Hiroshi. Nakamura;Y. Hamada
中科院分区：
文献类型：
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作者：
T. Nemoto;L. Jin;Hiroshi. Nakamura;Y. Hamada
摘要研究了天门冬氨酸衍生的P-氨基氧化二氨基膦[(S, R P)-Ph-DIAPHOX]在pd催化下与硝基甲烷的不对称烯丙基烷基化反应。该方法成功地应用于(R)-preclamol和(R)-baclofen的对映选择性合成。
Abstract A Pd-catalyzed asymmetric allylic alkylation with nitromethane using an aspartic acid-derived P-chirogenic diaminophosphine oxide [( S , R P )-Ph-DIAPHOX] is described. This method was successfully applied to enantioselective synthesis of ( R )-preclamol and ( R )-baclofen.