Progress on the Design and Development of the Continuous-Flow Total Artificial Heart
Progress on the Design and Development of the Continuous-Flow Total Artificial Heart
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DOI：
10.1111/j.1525-1594.2012.01489.x
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发表时间：
2012-08-01
影响因子：
2.4
通讯作者：
Golding, Leonard A. R.
中科院分区：
文献类型：
--
作者：
Kobayashi, Mariko;Horvath, David J.;Golding, Leonard A. R.
克利夫兰诊所的连续流动全人工心脏有一个电机和一个旋转组件支持的流体动力轴承。右液压输出通过旋转组件的被动轴向运动进行自我调节，以使其自身与左输出保持平衡。本文的目的是介绍四个开发领域的进展：自动速度控制系统、平衡右/左入口压力和流量的自我调节、使用小牛血的溶血测试以及耦合电磁学（EMAG）和计算流体动力学（CFD）分析。电机功率和速度，体循环流量和体循环血管阻力（SVR）的功能之间的关系被用于无传感器速度控制算法，并表现出密切的相关性。基于这些经验关系，在系统模块中计算系统流量和SVR，并与测量的泵流量和SVR显示出良好的相关性。自动系统根据计算的SVR调整泵的速度以获得目标流量。对于广泛的SVR/肺血管阻力比，心房压差（左心房压减去右心房压）保持在+/- 10 mm Hg范围内，证明在固定速度模式和25%正弦调制速度模式下具有广泛的自我调节范围。溶血试验结果表明可接受的值（标准化溶血指数
Cleveland Clinic's continuous-flow total artificial heart has one motor and one rotating assembly supported by a hydrodynamic bearing. The right hydraulic output is self regulated by passive axial movement of the rotating assembly to balance itself with the left output. The purpose of this article is to present progress in four areas of development: the automatic speed control system, self-regulation to balance right/left inlet pressures and flows, hemolysis testing using calf blood, and coupled electromagnetics (EMAG) and computational fluid dynamics (CFD) analysis. The relationships between functions of motor power and speed, systemic flow, and systemic vascular resistance (SVR) were used for the sensorless speed control algorithm and demonstrated close correlations. Based on those empirical relationships, systemic flow and SVR were calculated in the system module and showed good correlation with measured pump flow and SVR. The automatic system adjusted the pump's speed to obtain the target flow in response to the calculated SVR. Atrial pressure difference (left minus right atrial pressure) was maintained within +/- 10 mm Hg for a wide range of SVR/pulmonary vascular resistance ratios, demonstrating a wide margin of self-regulation under fixed-speed mode and 25% sinusoidally modulated speed mode. Hemolysis test results indicated acceptable values (normalized index of hemolysis