Antipyrine metabolism in man: Influence of age, alcohol, caffeine, and smoking
Antipyrine metabolism in man: Influence of age, alcohol, caffeine, and smoking
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男性安替比林代谢：年龄、酒精、咖啡因和吸烟的影响
DOI：
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发表时间：
1975
期刊：
影响因子：
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通讯作者：
R. Andres
中科院分区：
文献类型：
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作者：
R. Vestal;A. H. Norris;J. Tobin;Bernice H. Cohen;N. Shock;R. Andres
年龄已被证明会影响药物代谢，但衰老的影响可能是由于影响代谢并随年龄而变化的其他变量造成的。在 307 名 18 至 92 岁的健康男性受试者中研究了安替比林的血浆半衰期和代谢清除率。与年轻受试者相比，老年受试者的半衰期长 16.5%，代谢清除率低 18.5%。老年受试者的酒精消耗量、咖啡因消耗量和吸烟量均较低。咖啡因和吸烟均与安替比林代谢率呈正相关。多元回归分析表明，吸烟的影响是造成安替比林代谢年龄差异的部分原因。吸烟解释了代谢清除率差异的 12%，年龄解释了 3%。我们的结果表明，试图量化衰老对药物代谢影响的研究还必须考虑随年龄变化的其他因素。
Age has been shown to influence drug metabolism but effects of aging could be due to other variables that influence metabolism and differ with age. Plasma half‐life and metabolic clearance rate of antipyrine were studied in 307 healthy male subjects, aged 18 to 92. Half‐life was 16.5 % longer and metabolic clearance rate was 18.5% less in a group of the older than in the younger subjects. Alcohol consumption, caffeine consumption, and cigarette smoking all were lower in the older subjects. Both caffeine and cigarette use were positively correlated with the rate of antipyrine metabolism. Multiple regression analysis showed that the effect of smoking was partially responsible for the age differences in antipyrine metabolism. Smoking explained 12% of the variance in metabolic clearance rate and age explained 3%. Our results suggest that studies attempting to quantify the effects of aging on drug metabolism must also take into account other factors that differ with age.