Adult-type hypolactasia and calcium intake in polycystic ovary syndrome
Adult-type hypolactasia and calcium intake in polycystic ovary syndrome
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DOI：
10.1111/j.1365-2265.2012.04334.x
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发表时间：
2012-12-01
影响因子：
3.2
通讯作者：
Obermayer-Pietsch, Barbara
中科院分区：
文献类型：
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作者：
Lerchbaum, Elisabeth;Giuliani, Albrecht;Obermayer-Pietsch, Barbara
目的成人型低乳酸血症（ATH）与低钙、低牛奶摄入有关，可能与肥胖及代谢紊乱有关。患有多囊卵巢综合征（PCOS）的妇女经常遭受代谢紊乱，包括中心性肥胖。我们的目的是研究多囊卵巢综合征和对照组妇女中ATH和钙摄入量与人体测量、代谢和内分泌参数的关系。设计对504例PCOS妇女和366例对照妇女进行代谢、内分泌、人体测量和口服葡萄糖耐量试验。进行了ATH的基因分型，由MCM 6基因的-13910变体定义。通过问卷调查评估钙摄入量。结果PCOS组成人型低乳糖血症的发生率（29.8%）高于对照组（23.5%）（P = 0.040）。PCOS合并ATH的妇女腰臀比（WHR）（0.80 [0.750.88] vs 0.78 [0.730.85]，P = 0.046），葡萄糖2 h（5.28 [4.576.33] mmol/l vs 5.67 [4.686.78] mmol/l，P = 0.037），HbA1c（5.2 [5.05.4]%vs 5.1 [5.05.3]%，P = 0.009），甲状旁腺激素（3.72 [2.914.86] pmol/l vs 3.61 [2.944.63] pmol/l，P = 0.030）和Ferriman-Gallwey评分（FG评分）（7 [312] vs 4 [19]，P = 0.002）和25（OH）D水平（54.4 [35.280.6] nmol/l vs 68.4 [49.789.4] nmol/l，P < 0.001）低于无ATH的PCOS妇女。在年龄、BMI和WHR校正分析中，25（OH）D和FG评分与ATH的相关性仍然显著。与钙摄入量较低的PCOS妇女相比，钙摄入量最高四分位数的PCOS妇女睾酮（P = 0.023）和雄烯二酮（P = 0.032）显著降低，高密度脂蛋白（HDL）水平显著升高（P = 0.035）。结论ATH与PCOS易感性有关。此外，ATH可能影响WHR、HbA 1c和FG评分以及25（OH）D水平。高钙摄入量与低雄激素和高HDL水平相关。
Objective Adult-type hypolactasia (ATH) is related to lower calcium and milk intake, which might be associated with obesity and metabolic disturbances. Women with polycystic ovary syndrome (PCOS) frequently suffer from metabolic disturbances including central obesity. We aimed to examine the association of ATH and calcium intake with anthropometric, metabolic and endocrine parameters in a cohort of PCOS and control women. Design Metabolic, endocrine and anthropometric measurements and oral glucose tolerance tests were performed in 504 PCOS and 366 control women. Genotyping of ATH, defined by the -13910 variant of the MCM6 gene, was performed. Calcium intake was assessed by questionnaires. Results Adult-type hypolactasia was more prevalent in PCOS women (29.8%) than in controls (23.5%) (P = 0.040). PCOS women with ATH had higher waist-to-hip ratio (WHR) (0.80 [0.750.88] vs 0.78 [0.730.85], P = 0.046), glucose 2 h (5.28 [4.576.33] mmol/l vs 5.67 [4.686.78] mmol/l, P = 0.037), HbA1c (5.2 [5.05.4]%vs 5.1 [5.05.3]%, P = 0.009), parathyroid hormone (3.72(2.914.86] pmol/l vs 3.61 [2.944.63] pmol/l, P = 0.030) and Ferriman-Gallwey-Scores (FG Scores) (7 [312] vs 4 [19], P = 0.002) and lower 25(OH)D levels (54.4 [35.280.6] nmol/l vs 68.4 [49.789.4] nmol/l, P < 0.001) than PCOS women without ATH. The association of 25(OH)D and FG-Scores with ATH remained significant in age-, BMI- and WHR-adjusted analyses. PCOS women within the highest quartile of calcium intake had significantly lower testosterone (P = 0.023) and androstenedione (P = 0.032) and significantly higher high-density lipoprotein (HDL) levels (P = 0.035) than PCOS women with lower calcium intake. Conclusion Our results indicate an association of ATH with PCOS susceptibility. Moreover, ATH might influence WHR, HbA1c and FG-Scores as well as 25(OH)D levels. Higher calcium intake was associated with lower androgens and higher HDL levels.