Saline irrigation does not affect bone formation or fixation strength of hydroxyapatite/tricalcium phosphate-coated implants in a rat model
Saline irrigation does not affect bone formation or fixation strength of hydroxyapatite/tricalcium phosphate-coated implants in a rat model
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DOI：
10.1002/jbm.b.30293
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发表时间：
2005-08-01
影响因子：
3.4
通讯作者：
Sumner, DR
中科院分区：
文献类型：
--
作者：
De Ranieri, A;Virdi, AS;Sumner, DR
膜内骨再生对于种植体固定至关重要。在非骨水泥关节置换术中（与骨水泥关节置换术相反），手术期间通常不进行盐水冲洗，以便保留骨髓提供的成骨刺激。几个小组现在正在使用大鼠骨髓消融模型来研究膜内骨再生和植入物固定。在该模型中，骨髓内容物被机械破坏，碎片通常通过盐水冲洗清除，这一步骤似乎与临床情况不一致。此外，与传统观点相反，据报道，盐水冲洗增强了大鼠模型中的骨-种植体接触和种植体周围骨形成（Ishizaka等人，Bone 1996；19：589-594），尽管没有研究种植体的机械固定。因此，本研究的目的是确定盐水冲洗是否会增强大鼠模型中植入物的机械固定。 48只400～450g雄性大鼠，平均分为两组。与对照组相反，治疗组在放置羟基磷灰石/磷酸三钙涂层植入物之前在消融的髓管中接受盐水冲洗。每组中的 8 只动物在植入后 2、4 或 8 周被处死，此时通过显微计算机断层扫描分析标本以测量植入物周围的骨形成，然后进行机械拔出测试以测量植入物的固定强度。正如预期的那样，固定强度随着时间的推移而增加，但两组之间种植体周围骨体积、骨-种植体接触或种植体固定强度没有显着差异。因此，在这项植入物具有骨传导涂层的研究中，我们发现盐水冲洗对骨形成或植入物固定强度没有影响。 (c) 2005 年 Wiley 期刊公司。
Intramembranous bone regeneration is critical to implant fixation. In cementless joint replacement (as opposed to cemented joint replacement), saline irrigation is not typically performed during surgery so that the osteogenic stimulus provided by the marrow is preserved. Several groups are now using the rat marrow ablation model to study intramembranous bone regeneration and implant fixation. In this model, the marrow contents are mechanically disrupted, and debris is often cleared by saline irrigation, a step that appears inconsistent with the clinical situation. Furthermore, in contrast to conventional wisdom, it has been reported that saline irrigation enhanced bone-implant contact and peri-implant bone formation in the rat model (Ishizaka et al. Bone 1996;19:589-594), although mechanical fixation of the implant was not investigated. Accordingly, the present study was performed to determine if saline irrigation leads to enhanced mechanical fixation of implants in the rat model. Forty-eight 400 to 450 g male rats were divided equally into two groups. The treatment group, in contrast to the control group, received saline irrigation in the ablated medullary canal prior to placement of hydroxyapatite/tricalcium phosphate-coated implants. Eight animals in each group were killed at 2, 4, or 8 weeks after implantation, at which time the specimens were analyzed by micro computed tomography to measure bone formation around the implant, followed by a mechanical pull-out test to measure the strength of fixation of the implant. As expected, there was increased fixation strength over time, but there were no significant differences in peri-implant bone volume, bone-implant contact, or implant fixation strength between the two groups. Thus, we found no effect of saline irrigation on bone formation or implant fixation strength in this study in which the implant had an osteoconductive coating. (c) 2005 Wiley Periodicals, Inc.