Physiological and Metabolic Characteristics of a Cohort of Transgender and Gender-Diverse Youth in the United States.
Physiological and Metabolic Characteristics of a Cohort of Transgender and Gender-Diverse Youth in the United States.
复制标题
美国跨性别和性别多元化青年群体的生理和代谢特征。
DOI：
10.1016/j.jadohealth.2020.03.028
复制
发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Chan,Yee-Ming
中科院分区：
文献类型：
--
作者：
Millington,Kate;Schulmeister,Caroline;Finlayson,Courtney;Grabert,Ren;Olson-Kennedy,Johanna;Garofalo,Robert;Rosenthal,StephenM;Chan,Yee-Ming
目的：本研究的目的是描述美国最大的跨性别和性别多样化（TGD）青年前瞻性研究中参与者的基线身体和实验室特征。方法在开始GnRH类似物治疗青春期抑制或性别肯定激素治疗之前，从四家专门从事TGD青年护理的诊所招募参与者。人体测量和实验室测量从医学图表中摘录。基线特征包括身高、体重、身体质量指数、血压和实验室测量与年龄匹配的国家健康和营养检查调查对照组进行比较。结果在青春期抑制前招募年龄中位数为11岁（8 ~ 14岁）的TGD青年78人，其中出生时为男性41人（53%）；在开始使用性别确认激素前招募年龄中位数为16岁（12 ~ 20岁）的296人，其中出生时为男性99人（33%）。与全国健康与营养调查参与者相比，研究参与者的平均高密度脂蛋白胆固醇较低（50.6±12.3 mg/dL vs. 53.3±13.3 mg/dL,p= .001）。除此之外，研究队列在体重指数、超重和肥胖比例、血压和基线实验室变量方面相似。结论：在开始性别确认治疗之前，TGD青少年在生理上与美国普通儿童和青少年相似，只是高密度脂蛋白胆固醇略低。随着时间的推移，对这一队列的评估将确定青春期阻断和性别肯定激素治疗的生理效果。
PurposeThe purpose of this study was to describe baseline physical and laboratory characteristics of participants in the largest prospective study of transgender and gender-diverse (TGD) youth in the United States.MethodsParticipants were recruited from four clinics which specialize in the care of TGD youth before starting either GnRH analogs for pubertal suppression or gender-affirming hormone treatment. Anthropometric and laboratory measurements were abstracted from the medical chart. Baseline characteristics including height, weight, body mass index, blood pressure, and laboratory measurements were compared with those of age-matched National Health and Nutritional Examination Survey comparison group.ResultsSeventy-eight TGD youth with a median age of 11 years (range 8–14 years) were recruited before pubertal suppression, of whom 41 (53%) were designated male at birth, and 296 participants with a median age of 16 years (range 12–20 years) were recruited before beginning gender-affirming hormones, of whom 99 (33%) were designated male at birth. The mean high-density lipoprotein cholesterol was lower in the study participants when compared with that of National Health and Nutritional Examination Survey participants (50.6 ± 12.3 mg/dL vs. 53.3 ± 13.3 mg/dL,p= .001). Otherwise, the study cohorts were similar in terms of body mass index, proportion of overweight and obesity, blood pressure, and baseline laboratory variables.ConclusionsBefore starting gender-affirming treatment, TGD youth are physiologically similar to the general population of children and adolescents in the United States, with the exception of slightly lower high-density lipoprotein cholesterol. Evaluation of this cohort over time will define the physiological effects of pubertal blockade and gender-affirming hormone treatment.