Association Between IFN-γ Gene Polymorphisms and IgA Nephropathy in a Chinese Han Population
Association Between IFN-γ Gene Polymorphisms and IgA Nephropathy in a Chinese Han Population
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DOI：
10.1159/000473889
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发表时间：
2017-01-01
影响因子：
2.8
通讯作者：
Fu，Rongguo
中科院分区：
文献类型：
--
作者：
Gao，Jie;Wei，Linting;Fu，Rongguo
背景/目的：IFN-γ参与了免疫球蛋白A肾病（IgAN）的发生和发展，但IFN-γ基因多态性与IgAN的相关性研究较少。方法：采用Sequenom MassARRAY方法对351例IgAN患者和310例健康对照者的rs 1861494和rs 2430561基因多态性进行分析。结果：IFN-γ rs 1861494与IgA肾病的危险性及临床指标均无相关性。IgAN患者rs 2430561基因AA型频率高于对照组（AT vs. AA：OR = 0.57，P = 0.035），IFN-γ-rs 2430561 T等位基因可能是IgAN易感性的保护因素（T vs. A：OR = 0.59，P = 0.04）。基于临床特征的亚组分析显示rs 2430561多态性与性别、24 h尿蛋白定量、血压、牛津分级和估计肾小球滤过率等临床数据无显著相关性。IgAN患者血清IFN-γ水平高于健康对照组，rs 1861494 AA基因型患者血清IFN-γ水平高于AG/GG基因型患者。
Background/Aims:IFN-γwas reported to be involved in the development and progression of Immunoglobulin A nephropathy (IgAN), however, few studies have investigated the association betweenIFN-γpolymorphisms and IgAN. Therefore, we performed a case-control study to assess the association betweenIFN-γpolymorphisms and the risk of IgAN.Methods:Sequenom MassARRAY was used to genotype two SNPs (rs1861494 and rs2430561) in 351 patients with IgAN and 310 healthy controls. Associations were evaluated as odd ratios (OR) with 95% confidence intervals (CI).Results:No association was found betweenIFN-γrs1861494 and IgAN risk or clinical parameters. For rs2430561, the AA genotype was more common in patients with IgAN, compared with controls (AT vs. AA: OR = 0.57, P = 0.035).IFN-γ-rs2430561 T allele may be a protective factor for IgAN susceptibility (T vs. A: OR = 0.59, P = 0.04). Subgroup analysis based on clinical features revealed no significant association between rs2430561 polymorphism and clinical data such as gender, 24-h urine protein, blood pressure, Oxford classifcation and estimated glomerular fltration rate. IgAN patients had a higherIFN-γserum level than healthy controls and patients with rs1861494 AA genotype had a higherIFN-γserum level compared with those with AG/GG genotypes.Conclusions:IFN-γpolymorphisms may be involved in the development and progression of IgAN.