Calcium imaging of cortical networks dynamics
Calcium imaging of cortical networks dynamics
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DOI：
10.1016/j.ceca.2005.01.013
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发表时间：
2005-05-01
期刊：
影响因子：
4
通讯作者：
Yuste, R
中科院分区：
文献类型：
--
作者：
Cossart, R;Lkegaya, Y;Yuste, R
有关自发网络活动的认知过程和/或大脑疾病的研究构成了最近不断扩大的调查领域。它们大多基于细胞记录（通常在脑切片中进行电诱发振荡）或使用四极或多电极的多细胞记录，但是这些研究策略不能将电记录与神经元的形态特征联系起来。在成像技术的进展允许第一次同时具有网络活动的动态和全局特性，并确定参与此活动的单一微电路的单细胞特性。(c)2005爱思唯尔有限公司保留所有权利。
Studies relating spontaneous network activities to cognitive processes and/or brain disorders constitute a recently expanding field of investigation. They are mostly based either on cellular recordings-usually performed in pharmacologically induced oscillations in brain slices-or on multi-cellular recordings using tetrodes or multiple electrodes.However, these research strategies cannot link the electrical recordings with morphological characterization of the neurons. The progress made in imaging techniques allows for the first time to have simultaneously a dynamic and global characterization of network activity and to determine the single-cell properties of the unitary microcircuits involved in this activity. (c) 2005 Elsevier Ltd. All rights reserved.