Methionine-Restricted Diet: A Feasible Strategy Against Chronic or Aging-Related Diseases
Methionine-Restricted Diet: A Feasible Strategy Against Chronic or Aging-Related Diseases
复制标题
限制蛋氨酸饮食：对抗慢性或衰老相关疾病的可行策略
DOI：
10.1021/acs.jafc.2c05829
复制
发表时间：
2022-12-26
影响因子：
6.1
通讯作者：
Le，Guowei
中科院分区：
文献类型：
--
作者：
Wu，Guoqing;Xu，Jingxuan;Le，Guowei
膳食蛋氨酸限制(MR)与多方面的健康促进作用有关。MR有助于预防几种慢性病和癌症，延长寿命。在过去的五年里，关于MR的新表型和机制的研究越来越多，特别是在血管生成、神经退行性疾病、肠道微生物区系和肠道屏障功能方面。在这篇综述中，我们总结了MR的特点和优势，以及MR在慢性疾病和衰老相关病理中的生理反应和作用的研究现状。讨论了硫化氢、成纤维细胞生长因子21、肠道微生物区系、短链脂肪酸等可能的作用机制。此外，对表观遗传学和肠道微生物区系在MR饮食中的发展方向进行了展望。该综述全面总结了MR在预防慢性病和衰老方面的新作用和新机制的解释。
Dietary methionine restriction (MR) has been associated with multifaceted health-promoting effects. MR is conducive to prevention of several chronic diseases and cancer, and extension of lifespan. A growing number of studies on new phenotypes and mechanisms of MR have become available in the past five years, especially in angiogenesis, neurodegenerative diseases, intestinal microbiota, and intestinal barrier function. In this review, we summarize the characteristics and advantages of MR, and current knowledge on the physiological responses and effects of MR on chronic diseases and aging-associated pathologies. Potential mechanisms, in which hydrogen sulfide, fibroblast growth factor 21, gut microbiota, short-chain fatty acids, and so on are involved, are discussed. Moreover, directions for epigenetics and gut microbiota in an MR diet are presented in future perspectives. This review comprehensively summarizes the novel roles and interpretations of the mechanisms underlying MR in the prevention of chronic diseases and aging.