WT1/EGR1-mediated control of STIM1 expression and function in cancer cells.
WT1/EGR1-mediated control of STIM1 expression and function in cancer cells.
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DOI：
10.2741/3862
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发表时间：
2011-06-01
期刊：
影响因子：
--
通讯作者：
Soboloff J
中科院分区：
文献类型：
--
作者：
Ritchie MF;Zhou Y;Soboloff J
已经有许多出版物将Ca 2+信号传导与癌症联系起来，然而，对这些差异的明确解释仍然难以捉摸。我们最近确定了癌基因/肿瘤抑制因子Wilms Tumor Suppressor 1（WT 1）和早期生长反应1（EGFR 1）作为STIM 1表达的调节因子，STIM 1是不可兴奋细胞中Ca 2+进入的重要调节因子。目前的审查重点是文献定义的差异Ca 2+信号和WT 1/EGR 1的表达模式在5个特定的癌症亚型：急性髓性白血病，肾母细胞瘤，乳腺癌，胶质母细胞瘤和前列腺癌。对于每种肿瘤类型，我们评估了WT 1和EGR 1表达的特定变化如何导致异常的Ca 2+稳态以及这些观察结果的治疗潜力。
There have been numerous publications linking Ca2+ signaling and cancer, however, a clear explanation for these differences has remained elusive. We recently identified the oncogenes/tumor suppressors Wilms Tumor Suppressor 1 (WT1) and Early Growth Response 1 (EGR1) as regulators of the expression of STIM1, an essential regulator of Ca2+ entry in non-excitable cells. The current review focuses on the literature defining both differential Ca2+ signaling and WT1/EGR1 expression patterns in 5 specific cancer subtypes: Acute Myeloid Leukemia, Wilms Tumor, breast cancer, glioblastoma and prostate cancer. For each tumor-type, we have assessed how specific changes in WT1 and EGR1 expression might contribute to aberrant Ca2+ homeostasis as well as the therapeutic potential of these observations.
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