GLYCOSYLTRANSFERASES IN HUMAN BLOOD .2. STUDY OF SERUM GALACTOSYLTRANSFERASE AND N-ACETYLGALACTOSAMINYLTRANSFERASE IN PATIENTS WITH LIVER-DISEASES
GLYCOSYLTRANSFERASES IN HUMAN BLOOD .2. STUDY OF SERUM GALACTOSYLTRANSFERASE AND N-ACETYLGALACTOSAMINYLTRANSFERASE IN PATIENTS WITH LIVER-DISEASES
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DOI：
10.1172/jci107009
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发表时间：
1972-01-01
影响因子：
15.9
通讯作者：
CURTIS, KJ
中科院分区：
文献类型：
--
作者：
KIM, YS;PERDOMO, J;CURTIS, KJ
血清半乳糖转移酶活性在酒精性和其他肝脏疾病患者中升高，但在各种非肝脏疾病患者中保持正常水平。比较了肝病患者血清半乳糖转移酶与正常人血清半乳糖转移酶的性质。检查血清中可能存在的抑制剂或激活剂。结果表明，在肝病患者中，血清半乳糖转移酶的升高是由于正常血清中存在的酶水平的增加，而不是由于新酶的出现。在所检查的病例中，酶的水平随着肝功能的恶化而升高，在急性酒精性肝炎恢复的患者中下降。另一种糖基转移酶，ann -乙酰半乳糖氨基转移酶，在肝病患者的血清中没有升高，与半乳糖氨基转移酶不同，在正常肝脏中未检测到。结果表明，血清半乳糖转移酶起源于肝脏，血清中该酶水平的异常升高是由于肝细胞损伤所致。
Serum galactosyltransferase activity was found to be elevated in patients with alcoholic and other liver disorders but remained at a normal level in patients with a variety of nonhepatic diseases. The properties of the galactosyltransferase in patients with liver disease were compared with those of the enzyme in the serum of normal subjects. The possible presence of inhibitors or activators in the serum was examined. Results indicated that in patients with liver disease, the rise in the serum galactosyltransferase was due to an increase in the level of the enzyme present in normal serum and not due to the appearance of a new enzyme. In the cases examined, the level of the enzyme increased with the deterioration of liver function and declined in a patient recovering from acute alcoholic hepatitis. Another glycosyltransferase, anN-acetylgalactosaminyltransferase, was not elevated in the serum of liver disease patients and, unlike the galactosyltransferase, was not detected in normal liver. The results suggest that the serum galactosyltransferase originates from the liver and that an abnormal rise in the level of this enzyme in serum is due to hepatocellular damage.