Hepatitis A vaccine associated with autoimmune hepatitis
Hepatitis A vaccine associated with autoimmune hepatitis
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DOI：
10.3748/wjg.v13.i15.2238
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发表时间：
2007-04-21
影响因子：
4.3
通讯作者：
Smith-Laing, G.
中科院分区：
文献类型：
--
作者：
Berry, P. A.;Smith-Laing, G.
描述一例与甲型肝炎病毒（HAV）疫苗接种相关的可能复发的自身免疫性肝炎。撰写了有关与甲型肝炎和其他嗜肝病毒相关的自身免疫性肝炎的病例报告和文献综述。在正式接种灭活甲型肝炎疫苗后不久，一名最近从未特征性但自限性肝炎疾病中恢复的男性出现严重恶化（AST 1687 U/L，INR 1.4）。抗核抗体可检测，肝活检符合自身免疫性肝炎。这一观察结果支持甲型肝炎病毒作为自身免疫性肝炎的触发因素的作用。本文总结了甲型肝炎感染背景下辅助性T细胞活性和抗肝蛋白抗体表达的研究，并简要探讨了与其他形式的病毒性肝炎和自身免疫有关的分子模拟概念。(c)2007年，WJG出版社。版权所有
To describe a case of probable relapsing autoimmune hepatitis associated with vaccination against hepatitis A virus (HAV). A case report and review of literature were written concerning autoimmune hepatitis in association with hepatitis A and other hepatotropic viruses. Soon after the administration of formal in-inactivated hepatitis A vaccine, a man who had recently recovered from an uncharacterized but self-limiting hepatitic illness, experienced a severe deterioration (AST 1687 U/L, INR 1.4). Anti-nuclear antibodies were detectable, and liver biopsy was compatible with autoimmune hepatitis. The observation supports the role of HAV as a trigger of autoimmune hepatitis. Studies in helper T-cell activity and antibody expression against hepatic proteins in the context of hepatitis A infection are summarized, and the concept of molecular mimicry with regard to other forms of viral hepatitis and autoimmunity is briefly explored. (c) 2007 The WJG Press. All rights reserved