The cross-tolerance hypothesis, HLA-B27 and ankylosing spondylitis.
The cross-tolerance hypothesis, HLA-B27 and ankylosing spondylitis.
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交叉耐受假说、HLA-B27 和强直性脊柱炎。
DOI：
10.1093/rheumatology/xxii.suppl_2.53
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
A. Ebringer
中科院分区：
文献类型：
--
作者：
A. Ebringer
人类白细胞抗原B27与强直性脊柱炎(AS)的相关性可以用交叉耐受假说来解释，即革兰氏阴性菌，如克雷伯氏菌，具有类似于人类白细胞抗原B27的抗原。对人类组织分型血清和兔抗克雷伯氏菌血清的实验研究似乎符合这一假设。临床研究表明，无论临床上有无葡萄膜炎，或通过血沉和C反应蛋白水平的升高，粪便克雷伯氏菌可以更容易地从疾病活动期的AS患者身上分离出来。交叉耐受假说认为，强直性脊柱炎是感染革兰氏阴性菌后的反应性关节炎，组织损伤是由抗菌抗体与交叉反应的自身抗原结合而产生的。
The association of HLA-B27 with ankylosing spondylitis (AS) can be explained by a cross-tolerance hypothesis, which suggests that Gram-negative bacteria, such as Klebsiella, possess antigens which resemble HLA-B27. Experimental studies with human tissue-typing sera and rabbit anti-Klebsiella sera would appear to be compatible with this hypothesis. Clinical studies indicate that faecal Klebsiella can be isolated more readily from AS patients during active phases of the disease, when this is defined either clinically, with or without uveitis, or biochemically by elevation in ESR and C-reactive protein levels. The cross-tolerance hypothesis proposes that ankylosing spondylitis is a reactive arthritis following infection by Gram-negative bacteria and tissue damage is produced by antibacterial antibody binding to cross-reacting self-antigens.