Diabetes mellitus related bone metabolism and periodontal disease.
Diabetes mellitus related bone metabolism and periodontal disease.
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DOI：
10.1038/ijos.2015.2
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发表时间：
2015-06-26
影响因子：
14.9
通讯作者：
Graves DT
中科院分区：
文献类型：
--
作者：
Wu YY;Xiao E;Graves DT
糖尿病和牙周病是影响全球大量人口的慢性病。骨代谢异常是糖尿病长期存在的重要并发症之一。牙槽骨丢失是牙周炎的主要后果之一，糖尿病是牙周病的主要危险因素之一。在这篇综述中，我们总结了糖尿病对牙周炎患者牙周组织的不利影响，重点是牙槽骨丢失。骨重建始于破骨细胞吸收骨，然后吸收陷窝中的成骨细胞形成新骨。因此，我们讨论了与成骨细胞和破骨细胞有关的糖尿病促进骨丢失的潜在机制。
Diabetes mellitus and periodontal disease are chronic diseases affecting a large number of populations worldwide. Changed bone metabolism is one of the important long-term complications associated with diabetes mellitus. Alveolar bone loss is one of the main outcomes of periodontitis, and diabetes is among the primary risk factors for periodontal disease. In this review, we summarise the adverse effects of diabetes on the periodontium in periodontitis subjects, focusing on alveolar bone loss. Bone remodelling begins with osteoclasts resorbing bone, followed by new bone formation by osteoblasts in the resorption lacunae. Therefore, we discuss the potential mechanism of diabetes-enhanced bone loss in relation to osteoblasts and osteoclasts.