Plasma deuterium oxide accumulation following ingestion of different carbohydrate beverages
Plasma deuterium oxide accumulation following ingestion of different carbohydrate beverages
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DOI：
10.1139/h08-084
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发表时间：
2008-12-01
影响因子：
3.4
通讯作者：
Jeukendrup, Asker E.
中科院分区：
文献类型：
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作者：
Currell, Kevin;Urch, Joanna;Jeukendrup, Asker E.
从碳水化合物溶液(如口服补液溶液或运动饮料)中获得最佳的液体输送是至关重要的。这项研究的目的是调查含有葡萄糖和果糖的饮料是否会比只含葡萄糖的饮料产生更多的液体输送。6名男性受试者(平均年龄(+/-SD)：22+/-2岁)。受试者在隔夜禁食后的早上7点到9点之间进入实验室。然后给3种实验饮料中的1种600毫升。实验饮料是水(W)、75g葡萄糖(G)或50g葡萄糖和25g果糖(GF)；每种饮料还含有3.00g D2O。服用实验饮料后，受试者保持坐姿180分钟。然后，在第一个小时内每5分钟采集一次血液和唾液样本，此后每15分钟采集一次。血浆和唾液样品用同位素比值质谱仪分析。用双向重复测量方差分析比较氧化氢浓缩量。水试验(33+/-3min)达峰时间明显短于G(82+/-40min)或GF(59+/-25min)，但两者差异无统计学意义。与维也纳标准平均海水(VSMOW)相比，GF的AUC显著更高(55 673+/-10 020)。180min)和W(60497+/-9864增量比VSMOW)。180min)与G(46 290+/-9622增量百万分之VSMOW)相比。180min)，W和GF之间差异不显著。这些数据表明，12.5%的含葡萄糖和果糖的碳水化合物饮料在前75分钟内的液体输送速度比只含葡萄糖的饮料更快。
Optimal fluid delivery from carbohydrate solutions such as oral rehydration solutions or sports drinks is essential. The aim of the study was to investigate whether a beverage containing glucose and fructose would result in greater fluid delivery than a beverage containing glucose alone. Six male subjects were recruited (average age (+/- SD): 22 +/- 2 y). Subjects entered the laboratory between 0700h and 0900h after an overnight fast. A 600 mL bolus of 1 of the 3 experimental beverages was then given. The experimental beverages were water (W), 75 g glucose (G), or 50 g glucose and 25 g fructose (GF); each beverage also contained 3.00 g of D2O. Following administration of the experimental beverage subjects remained in a seated position for 180 min. Blood and saliva samples were then taken every 5 min in the first hour and every 15 min thereafter. Plasma and saliva samples were analyzed for deuterium enrichment by isotope ratio mass spectrometry. Deuterium oxide enrichments were compared using a 2-way repeated measures analysis of variance. The water trial (33 +/- 3 min) showed a significantly shorter time to peak than either G (82 +/- 40 min) or GF (59 +/- 25 min), but the difference between G and GF did not reach statistical significance. There was a significantly greater AUC for GF (55 673 +/- 10 020 delta parts per thousand vs. Vienna Standard Mean Ocean Water (VSMOW). 180min) and W (60 497 +/- 9864 delta parts per thousand vs. VSMOW. 180min) compared with G (46 290 +/- 9622 delta parts per thousand vs. VSMOW. 180min); W and GF were not significantly different from each other. These data suggest that a 12.5% carbohydrate beverage containing glucose and fructose results in more rapid fluid delivery in the first 75 min than a beverage containing glucose alone.