Chemical data mining of the NCI human tumor cell line database.
Chemical data mining of the NCI human tumor cell line database.
复制标题
NCI 人类肿瘤细胞系数据库的化学数据挖掘。
DOI：
10.1021/ci700141x
复制
发表时间：
2007
影响因子：
5.6
通讯作者：
Wild,DavidJ
中科院分区：
文献类型：
--
作者：
Wang,Huijun;Klinginsmith,Jonathan;Dong,Xiao;Lee,AdamC;Guha,Rajarshi;Wu,Yuqing;Crippen,GordonM;Wild,DavidJ
The NCI Developmental Therapeutics Program Human Tumor cell line data set is a publicly available database that contains cellular assay screening data for over 40 000 compounds tested in 60 human tumor cell lines. The database also contains microarray assay gene expression data for the cell lines, and so it provides an excellent information resource particularly for testing data mining methods that bridge chemical, biological, and genomic information. In this paper we describe a formal knowledge discovery approach to characterizing and data mining this set and report the results of some of our initial experiments in mining the set from a chemoinformatics perspective.
