Effect of Body Mass Index on Survival in Breast Cancer Patients According to Subtype, Metabolic Syndrome, and Treatment
Effect of Body Mass Index on Survival in Breast Cancer Patients According to Subtype, Metabolic Syndrome, and Treatment
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DOI：
10.1016/j.clbc.2018.04.010
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发表时间：
2018-10-01
影响因子：
3.1
通讯作者：
Ahn, Soohyun
中科院分区：
文献类型：
--
作者：
Cho, Won Kyung;Choi, Doo Ho;Ahn, Soohyun
体重指数（BMI）对乳腺癌患者生存的影响尚未确定。我们根据BMI对5668例接受根治性乳腺癌手术的患者的无病生存期（DFS）和总生存期（OS）进行了分析。BMI >= 25 kg/m(2)是DFS和OS的不利因素，特别是在管腔亚型疾病患者中。目的：探讨体重指数（BMI）对乳腺癌患者生存的影响，根据肿瘤亚型、代谢综合征及全身治疗情况进行分析。患者和方法：我们从单一机构的临床数据中确定了1996年至2013年间接受根治性手术的5668例乳腺癌患者。计算并比较BMI = 25 kg/m(2)和< 25 kg/m(2)的所有患者和特定亚组（包括肿瘤亚型、代谢综合征和全身治疗）的无病生存期（DFS）和总生存期（OS）。结果：在所有患者中，BMI >= 25 kg/m(2)是OS的不利因素（P= 0.030），而不是DFS的不利因素。在HR+ /HER2（-）亚组中，BMI < 25 kg/m(2)患者的DFS和OS时间长于>= 25 kg/m(2)患者(P = 0.012和。005年,分别)。在合并一种以上代谢综合征的患者中，BMI是OS的不利因素（危险比，2.669;P < .001）结论：BMI- 25 kg/m(2)是不利的生存因素，尤其是在HR+ /HER2-乳腺癌患者中。
Effect of body mass index (BMI) on survival in breast cancer patients has not yet been established. We analyzed disease-free survival (DFS) and overall survival (OS) of 5668 patients who underwent curative surgery for breast cancer according to BMI in several subgroups. BMI >= 25 kg/m(2) was an unfavorable factor for DFS and OS, particularly in patients with luminal subtype disease.Purpose: To investigate the effect of body mass index (BMI) on survival in patients with breast cancer according to tumor subtype, metabolic syndrome, and systemic treatment. Patients and Methods: We identified 5668 patients who underwent curative surgery for breast cancer between 1996 and 2013 from the clinical data of a single institution. Disease-free survival (DFS) and overall survival (OS) were calculated and compared between the patients with BMI >= 25 kg/m(2) and < 25 kg/m(2) in all patients and in specific subgroups, including tumor subtype, metabolic syndrome, and systemic treatment. Results: In all patients, BMI >= 25 kg/m(2) was an unfavorable factor for OS (P= .030) but not for DFS. In the HR+ /HER2(-) subgroup, DFS and OS were longer in patients with BMI < 25 kg/m(2) than >= 25 kg/m(2) (P = .012 and .005, respectively). In patients with more than one metabolic syndrome, BMI was an unfavorable factor for OS (hazard ratio, 2.669; P < .001) Conclusion: BMI- 25 kg/m(2) was an unfavorable survival factor, particularly in patients with HR+ /HER2- breast cancer.