DOPAMINERGIC INTERACTION WITH THE RESPIRATORY CONTROL-SYSTEM IN THE RAT
DOPAMINERGIC INTERACTION WITH THE RESPIRATORY CONTROL-SYSTEM IN THE RAT
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DOI：
10.1016/0014-2999(79)90417-5
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发表时间：
1979-01-01
影响因子：
5
通讯作者：
MUELLER, RA
中科院分区：
文献类型：
--
作者：
LUNDBERG, D;BREESE, GR;MUELLER, RA
用氟烷轻度麻醉的大鼠给予阿波吗啡会产生剂量依赖性的呼吸频率和分钟通气量增加。虽然阿波啡没有显著改变基底动脉CO2张力，但阿波啡对外源性CO2暴露的机械反应大大增加。氟哌啶醇使阿帕吗啡刺激的呼吸模式恢复到控制值。多巴胺神经元可能与呼吸控制有重要的相互作用。
Apomorphine given to rats lightly anesthetized with halothane produces a dose dependent increase in respiratory frequency and minute ventilation. Although basal arterial CO2 tensions were not significantly altered by apomorphine, the mechanical response to exogenous CO2 exposure was greatly increased in rats given apomorphine. Haloperidol returned the apomorphine-stimulated respiratory pattern to control values. Dopamine neurons may have important interactions with respiratory control.