Drugs as materials:: Valuing physical form in drug discovery
Drugs as materials:: Valuing physical form in drug discovery
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DOI：
10.1038/nrd1550
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发表时间：
2004-11-01
影响因子：
120.1
通讯作者：
Almarsson, Ö
中科院分区：
文献类型：
--
作者：
Gardner, CR;Walsh, CT;Almarsson, Ö
传统上，效力和选择性（以及某种程度上的代谢）一直是发现新候选药物过程中需要考虑的关键参数。最近，研究负责人和首席执行官们认识到一个新的现实：药物可以在体内移动并在分子水平上发挥作用，但需要识别和优化其物理形式的化学和材料特性，以实现体内性能、可靠制造和知识产权保护。这篇综述讨论了药物材料发现的挑战，并提出了解决药物发现和开发过程中物理化学和材料特性的表征和评估的策略。
Traditionally, potency and selectivity ( and to some extent metabolism) have been the key parameters to consider in the process of discovering new drug candidates. Recently, heads of research and CEOs have been learning a new reality: drugs can move around the body and act at the molecular level, but the chemical and material properties of their physical form need to be identified and optimized for in vivo performance, reliable manufacture and the protection of intellectual property. This review discusses the challenge of pharmaceutical materials discovery, and suggests strategies for addressing the characterization and evaluation of physico-chemical and material properties in the drug discovery and development process.