Dissecting the circuit for blindsight to reveal the critical role of pulvinar and superior colliculus
Dissecting the circuit for blindsight to reveal the critical role of pulvinar and superior colliculus
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DOI：
10.1038/s41467-018-08058-0
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发表时间：
2019-01-11
影响因子：
16.6
通讯作者：
Isa, Tadashi
中科院分区：
文献类型：
--
作者：
Kinoshita, Masaharu;Kato, Rikako;Isa, Tadashi
在初级视皮层（V1）受损的患者中，残余视觉可以在无意识的情况下引导目标导向运动到盲场中的目标。这种现象被称为盲视，其神经机制是有争议的。视觉通路应该是绕过V1到达高级视皮层的，但有些文献认为该信号是由上级丘和枕介导的，也有些文献认为是由外侧膝状体背核（dLGN）传递的。在这里，我们直接测试的作用SC腹外侧枕（vlPul）通路在盲猴。vIPul的药理学失活损害盲场中的视觉引导扫视（VGS）。通过组合两种病毒载体对SC-vIPul途径的选择性和可逆阻断也损害VGS。根据这些结果，我们声称SC-vIPul通路有助于盲视。这种差异可能是由于dLGN的退行性变性程度和用于评估的任务所致。
In patients with damage to the primary visual cortex (V1), residual vision can guide goal-directed movements to targets in the blind field without awareness. This phenomenon has been termed blindsight, and its neural mechanisms are controversial. There should be visual pathways to the higher visual cortices bypassing V1, however some literature propose that the signal is mediated by the superior colliculus (SC) and pulvinar, while others claim the dorsal lateral geniculate nucleus (dLGN) transmits the signal. Here, we directly test the role of SC to ventrolateral pulvinar (vlPul) pathway in blindsight monkeys. Pharmacological inactivation of vlPul impairs visually guided saccades (VGS) in the blind field. Selective and reversible blockade of the SC-vlPul pathway by combining two viral vectors also impairs VGS. With these results we claim the SC-vlPul pathway contributes to blindsight. The discrepancy would be due to the extent of retrograde degeneration of dLGN and task used for assessment.